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Cardiac Phase-Resolved T 2 * Magnetic Resonance Imaging Reveals Differences Between Normal Hearts and a Humanized Mouse Model of Hypertrophic Cardiomyopathy

Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Laghzali, Oumaima;
ORCID
0009-0004-1307-2166
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Shalikar, Shahriar;
ORCID
0000-0003-2817-892X
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Liu, Siqin;
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Lehmann, Sandra;
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Periquito, Joao dos Santos;
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Pohlmann, Andreas;
ORCID
0000-0002-9916-9572
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Waiczies, Sonia;
ORCID
0000-0001-8776-5820
Affiliation
Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;
Carrier, Lucie;
Affiliation
Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;
Yang, Hsin-Jung;
ORCID
0000-0001-7584-6527
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Niendorf, Thoralf;
ORCID
0000-0003-0963-2461
Affiliation
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Ultrahigh Field Facility (B.U.F.F.), 13092 Belin, Germany;(O.L.);(S.S.);(S.L.);(S.L.);(J.d.S.P.);(A.P.);(S.W.);(T.N.)
Ku, Min-Chi

Background/Objectives : While T 2 * mapping effectively assesses cerebral blood oxygenation, its utility for capturing cardiac phase-dependent myocardial changes in hypertrophic cardiomyopathy (HCM) is underexplored. This study investigates T 2 * dynamics in an HCM mouse model, to validate T 2 * as a clinically relevant biomarker for improved HCM diagnosis and treatment monitoring. Methods : A cardiac-specific Mybpc3 genetic mouse model, closely mirroring human HCM, was used with 12 young mice (6–11 weeks old), including both male and female wild-type (WT) and Mybpc3 -KI (HCM) groups. The cardiac function was assessed using self-gated multi-slice 2D CINE imaging. To investigate myocardial T 2 * variations across the cardiac cycle, multi-gradient echo (MGE) imaging was employed. This approach used retrospective gating and continuous acquisition synchronization with pulse oximetry at 9.4 T small animal MRI. Results : Mybpc3 -KI mice demonstrated left-ventricular (LV) hypertrophy compared to WT (HCM = 50.08 ± 4.68 µm/g vs. WT = 45.80 ± 20.07 µm/g, p < 0.01) and reduced ejection fraction (HCM = 38.55 ± 5.39% vs. WT= 72.53 ± 3.95%, p < 0.01). Myocardial T 2 * was significantly elevated in HCM across all cardiac phases (HCM = 12.14 ± 1.54 ms vs. WT = 7.93 ± 1.57 ms, p = 0.002). Strong correlations were observed between myocardial T 2 * and LV mass (rho = 0.88, p = 0.03). Conclusions : T 2 * was elevated in HCM with increased LV mass, highlighting the potential of T 2 * MRI as a sensitive biomarker for distinguishing healthy mice from those with HCM and revealing possible myocardial abnormalities.

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Editor:
Bang, Marie-Louise
Published in:
Biomedicines  
Vol. 13, No. 5 (14.05.2025)
Volume:
13
No.:
5
Date Issued:
14.05.2025
DOI:
10.3390/biomedicines13051193
Language:
English
Type of Resource:
Text
Keywords:
hypertrophic cardiomyopathy (HCM); myocardial tissue characterization; cardiac MRI; parametric imaging; T 2 * mapping
DDC:
610 Medizin und Gesundheit

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