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Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications

ORCID
0000-0003-4211-528X
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Salazar, Juan;
ORCID
0000-0002-7180-4765
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Ortega, Ángel;
ORCID
0000-0003-0914-5858
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Pérez, José Luis;
ORCID
0000-0002-5522-7697
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Garrido, Bermary;
ORCID
0000-0003-0761-5879
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Santeliz, Raquel;
ORCID
0000-0003-0765-2290
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Galbán, Néstor;
ORCID
0000-0001-6295-0229
Affiliation
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela;(J.S.);(Á.O.);(J.L.P.);(B.G.);(R.S.);(N.G.);(M.P.D.)
Díaz, Maria Paula;
ORCID
0000-0002-3692-9917
Affiliation
Clínica General del Norte, Grupo de Estudio e Investigación en Salud, Barranquilla 080002, Colombia;
Cano, Raquel;
ORCID
0000-0003-2874-5330
Affiliation
Institut für Pharmazie Königin-Luise, Freie Universität Berlin, Strasse 2-4, 14195 Berlin, Germany;
Cano, Gabriel;
ORCID
0000-0002-5179-5400
Affiliation
Departamento de Productividad e Innovación, Universidad de la Costa, Barranquilla 080002, Colombia;
Contreras-Velasquez, Julio Cesar;
ORCID
0000-0002-5208-9401
Affiliation
Centro de Investigaciones en Ciencias de la Vida (CICV), Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia
Chacín, Maricarmen

Although not frequently lethal, dermatological diseases represent a common cause of consultation worldwide. Due to the natural and non-invasive approach of phytotherapy, research for novel alternatives, such as polyphenols, to treat skin disorders is a subject of interest in modern medicine. Polyphenols, in particular, have been considered because of their anti-inflammatory, antitumoral, antimicrobial, and antioxidant properties, low molecular weight, and lipophilic nature that enables the passage of these compounds through the skin barrier. This review discusses the treatment of common dermatological diseases such as acne vulgaris, fungal infections, dermatitis, alopecia, and skin cancer, using polyphenols as therapeutic and prophylactic options. The specific molecules considered for each disorder, mechanisms of action, current clinical trials, and proposed applications are also reviewed.

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Editor:
Valdes, Miguel; Calzada, Fernando
Published in:
Pharmaceuticals  
Vol. 18, No. 2 (12.02.2025)
Volume:
18
No.:
2
Date Issued:
12.02.2025
DOI:
10.3390/ph18020247
Language:
English
Type of Resource:
Text
Keywords:
skin disorders; polyphenols; phytotherapy
DDC:
610 Medizin und Gesundheit

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License Holder: © 2025 by the authors.

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