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Myocardial DYRK1B Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing

Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Bayram, Fatma;
ORCID
0000-0003-1776-777X
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Hegner, Philipp;
ORCID
0009-0007-5054-3854
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Lauerer, Anna-Maria;
ORCID
0000-0001-7245-6902
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Schildt, Sönke;
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Wermers, Dominik;
ORCID
0000-0003-1722-7976
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Baier, Maria Johanna;
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Mustroph, Julian;
ORCID
0000-0003-3778-6716
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Tafelmeier, Maria;
Affiliation
Department of Cardiothoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany;(Z.P.);(C.S.)
Provaznik, Zdenek;
Affiliation
Department of Cardiothoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany;(Z.P.);(C.S.)
Schmid, Christof;
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Maier, Lars Siegfried;
ORCID
0000-0002-9471-1166
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Wagner, Stefan;
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Arzt, Michael;
ORCID
0000-0003-4525-797X
Affiliation
Department of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany;(F.B.);(P.H.);(A.-M.L.);(S.S.);(D.W.);(M.J.B.);(J.M.);(M.T.);(L.S.M.);(S.W.);(M.A.)
Lebek, Simon

Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial DYRK1B expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined DYRK1B mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardiac function as well as sleep-disordered breathing (SDB), including various oxidative stress parameters, were associated with an increased myocardial DYRK1B expression. A multivariate regression analysis revealed left ventricular ejection fraction and the presence of SDB as significant predictors of the myocardial DYRK1B expression independent of other clinical covariates. Based on these findings, DYRK1B represents a promising molecular target in patients with heart failure and reduced ejection fraction as well in patients with sleep-disordered breathing.

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Editor:
Angelone, Tommaso; De Bartolo, Anna; Rocca, Carmine
Published in:
Antioxidants  
Vol. 14, No. 2 (29.01.2025)
Volume:
14
No.:
2
Date Issued:
29.01.2025
DOI:
10.3390/antiox14020163
Language:
English
Type of Resource:
Text
Keywords:
DYRK1B; heart failure; sleep-disordered breathing; cardiovascular disease; hypoxia
DDC:
610 Medizin und Gesundheit

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