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Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke

Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Xu, Weilin;
Affiliation
Department of Neurosurgery ,Affiliated Tumor Hospital of Guangxi Medical University ,Nanning ,China
Yan, Jun;
Affiliation
Department of Medical Science Education ,College of Health Sciences ,Western University of Health Sciences ,Pomona ,CA ,United States
Travis, Zachary D.;
Affiliation
Burrell College of Osteopathic Medicine ,New Mexico State University ,Las Cruces ,NM ,United States
Lenahan, Cameron;
Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Gao, Liansheng;
Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Wu, Haijian;
Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Zheng, Jingwei;
Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Zhang, Jianmin;
Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Shao, Anwen;
Affiliation
Department of Neurosurgery ,Second Affiliated Hospital ,School of Medicine ,Zhejiang University ,Hangzhou ,Zhejiang ,China
Yu, Jun

The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.

Graphical Abstract The Apelin/APJ system exerted neuroprotection after stroke via decreasing ROS levels and increasing antioxidant protein expression.

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Published in:
Frontiers in Pharmacology
Vol. 15 (15.01.2025)
Volume:
15
Date Issued:
15.01.2025
DOI:
10.3389/fphar.2024.1352927
Language:
English
Type of Resource:
Text
Keywords:
apelin; APJ; stroke; oxidative stress; neuroprotection
DDC:
610 Medizin und Gesundheit

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License Holder: Copyright © 2025 Xu, Yan, Travis, Lenahan, Gao, Wu, Zheng, Zhang, Shao and Yu.

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