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The Preserflo MicroShunt Affects Microvascular Flow Density in Optical Coherence Tomography Angiography

ORCID
0000-0002-8063-6548
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Storp, Jens Julian;
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Schatten, Hannah;
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Vietmeier, Friederike Elisabeth;
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Merté, Ralph-Laurent;
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Lahme, Larissa;
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Zimmermann, Julian Alexander;
ORCID
0009-0006-5090-9206
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Englmaier, Verena Anna;
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Eter, Nicole;
ORCID
0000-0002-5536-8043
Affiliation
Department of Ophthalmology, University of Muenster Medical Center, 48149 Muenster, Germany(F.E.V.);(R.-L.M.);(L.L.);(J.A.Z.);(V.A.E.);(N.E.);(V.C.B.)
Brücher, Viktoria Constanze

Intraocular pressure (IOP) lowering surgery has been shown to alter microvascular density in glaucoma patients. The aim of this study is to report changes in retinal flow density (FD) over the course of treatment with the Preserflo MicroShunt, using optical coherence tomography angiography (OCTA). 34 eyes from 34 patients who underwent Preserflo MicroShunt implantation were prospectively enrolled in this study. OCTA imaging was conducted at the superficial (SCP), deep (DCP) and radial peripapillary plexus (RPC) levels. The progression of FD and IOP was assessed at different time points from baseline to six months postoperatively for the entire patient population, as well as disease severity subgroups. The Preserflo MicroShunt achieved a significant reduction in IOP over the course of six months (median: 8 mmHg; p < 0.01). FD values of the SCP and DCP did not show significant fluctuations, even after adjusting for disease severity. FD of the RPC decreased significantly over the course of six months postoperatively from 42.31 at baseline to 39.59 at six months postoperatively ( p < 0.01). The decrease in peripapillary FD was strongest in patients with advanced glaucoma (median: −3.58). These observations hint towards dysfunctional autoregulatory mechanisms in capillaries surrounding the optic nerve head in advanced glaucoma. In comparison, the microvascular structure of the macula appeared more resilient to changes in IOP.

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Editor:
Lu, Da-Wen
Published in:
Biomedicines  
Vol. 11, No. 12 (08.12.2023)
Volume:
11
No.:
12
Date Issued:
08.12.2023
DOI:
10.3390/biomedicines11123254
Language:
English
Type of Resource:
Text
Keywords:
  1. surgery
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    Schlagwort
  1. device
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    Schlagwort
  1. intraocular pressure
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    Schlagwort
  1. IOP
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    Schlagwort
  1. vessel density
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    Schlagwort
  1. MIGS
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    Schlagwort
  1. LIGS
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    Schlagwort
  1. glaucoma
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    Schlagwort
  1. severity
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    Schlagwort
DDC:
610 Medizin und Gesundheit

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