Feedback
  • Article / Essay
  • Different Effects of Phototherapy for Rat Glioma during Sleep and Wakefulness

Different Effects of Phototherapy for Rat Glioma during Sleep and Wakefulness

ORCID
0000-0003-4321-735X
Affiliation
Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences, Prospekt Entuziastov 13, 410049 Saratov, Russia
Shirokov, Alexander;
ORCID
0000-0003-1517-0857
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Blokhina, Inna;
Affiliation
Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.F.);(E.I.);(D.M.);(D.T.);(M.T.);(A.D.)
Fedosov, Ivan;
Affiliation
Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.F.);(E.I.);(D.M.);(D.T.);(M.T.);(A.D.)
Ilyukov, Egor;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Terskov, Andrey;
ORCID
0009-0002-7781-6721
Affiliation
Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.F.);(E.I.);(D.M.);(D.T.);(M.T.);(A.D.)
Myagkov, Dmitry;
Affiliation
Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.F.);(E.I.);(D.M.);(D.T.);(M.T.);(A.D.)
Tuktarov, Dmitry;
ORCID
0000-0002-4681-6465
Affiliation
Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.F.);(E.I.);(D.M.);(D.T.);(M.T.);(A.D.)
Tzoy, Maria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Adushkina, Viktoria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Zlatogosrkaya, Daria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Evsyukova, Arina;
ORCID
0000-0001-8411-6366
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Telnova, Valeria;
Affiliation
Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.F.);(E.I.);(D.M.);(D.T.);(M.T.);(A.D.)
Dubrovsky, Alexander;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Dmitrenko, Alexander;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Manzhaeva, Maria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Krupnova, Valeria;
ORCID
0009-0007-7450-7022
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Tuzhilkin, Matvey;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Elezarova, Inna;
ORCID
0000-0001-7876-9758
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Navolokin, Nikita;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Saranceva, Elena;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Iskra, Tatyana;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Lykova, Ekaterina;
ORCID
0000-0001-6753-7513
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.T.);(V.A.);(D.Z.);(A.E.);(V.T.);(A.D.);(M.M.);(V.K.);(M.T.);(I.E.);(N.N.);(E.S.);(T.I.);(E.L.)
Semyachkina-Glushkovskaya, Oxana

There is an association between sleep quality and glioma-specific outcomes, including survival. The critical role of sleep in survival among subjects with glioma may be due to sleep-induced activation of brain drainage (BD), that is dramatically suppressed in subjects with glioma. Emerging evidence demonstrates that photobiomodulation (PBM) is an effective technology for both the stimulation of BD and as an add-on therapy for glioma. Emerging evidence suggests that PBM during sleep stimulates BD more strongly than when awake. In this study on male Wistar rats, we clearly demonstrate that the PBM course during sleep vs. when awake more effectively suppresses glioma growth and increases survival compared with the control. The study of the mechanisms of this phenomenon revealed stronger effects of the PBM course in sleeping vs. awake rats on the stimulation of BD and an immune response against glioma, including an increase in the number of CD8+ in glioma cells, activation of apoptosis, and blockage of the proliferation of glioma cells. Our new technology for sleep-phototherapy opens a new strategy to improve the quality of medical care for patients with brain cancer, using promising smart-sleep and non-invasive approaches of glioma treatment.

Preview

Category

Editor:
Bacci, Stefano; Kang, Kyungsu
Published in:
Biomedicines  
Vol. 12, No. 2 (24.01.2024)
Volume:
12
No.:
2
Date Issued:
24.01.2024
DOI:
10.3390/biomedicines12020262
Language:
English
Type of Resource:
Text
Keywords:
  1. glioma
    Typ
    Schlagwort
  1. photobiomodulation
    Typ
    Schlagwort
  1. brain drainage
    Typ
    Schlagwort
  1. CD8+ cells
    Typ
    Schlagwort
  1. immune response
    Typ
    Schlagwort
DDC:
610 Medizin und Gesundheit

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:
open graphic

Rights

License Holder: © 2024 by the authors.

Use and reproduction: