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Machine Learning Technology for EEG-Forecast of the Blood–Brain Barrier Leakage and the Activation of the Brain’s Drainage System during Isoflurane Anesthesia

ORCID
0000-0001-6753-7513
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Semyachkina-Glushkovskaya, Oxana;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Sergeev, Konstantin;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Semenova, Nadezhda;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Slepnev, Andrey;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Karavaev, Anatoly;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Hramkov, Alexey;
ORCID
0000-0003-4069-9410
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Prokhorov, Mikhail;
ORCID
0000-0002-9621-039X
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Borovkova, Ekaterina;
ORCID
0000-0003-1517-0857
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Blokhina, Inna;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Fedosov, Ivan;
ORCID
0000-0003-4321-735X
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Shirokov, Alexander;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Dubrovsky, Alexander;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Terskov, Andrey;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Manzhaeva, Maria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Krupnova, Valeria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Dmitrenko, Alexander;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Zlatogorskaya, Daria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Adushkina, Viktoria;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Evsukova, Arina;
ORCID
0009-0007-7450-7022
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Tuzhilkin, Matvey;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Elizarova, Inna;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Ilyukov, Egor;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Myagkov, Dmitry;
Affiliation
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(K.S.);(N.S.);(A.S.);(A.K.);(M.P.);(E.B.);(I.F.);(A.D.);(E.I.);(D.T.)
Tuktarov, Dmitry;
Affiliation
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia;(I.B.);(A.S.);(A.T.);(M.M.);(V.K.);(A.D.);(D.Z.);(V.A.);(A.E.);(M.T.);(I.E.);(J.K.)
Kurths, Jürgen

Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes in the brain. There is growing evidence that anesthesia can disrupt the integrity of the blood–brain barrier (BBB), leading to neuroinflammation and neurotoxicity. However, there are no widely used methods for real-time BBB monitoring during surgery. The development of technologies for an express diagnosis of the opening of the BBB (OBBB) is a challenge for reducing post-surgical/anesthesia consequences. In this study on male rats, we demonstrate a successful application of machine learning technology, such as artificial neural networks (ANNs), to recognize the OBBB induced by isoflurane, which is widely used in surgery. The ANNs were trained on our previously presented data obtained on the sound-induced OBBB with an 85% testing accuracy. Using an optical and nonlinear analysis of the OBBB, we found that 1% isoflurane does not induce any changes in the BBB, while 4% isoflurane caused significant BBB leakage in all tested rats. Both 1% and 4% isoflurane stimulate the brain’s drainage system (BDS) in a dose-related manner. We show that ANNs can recognize the OBBB induced by 4% isoflurane in 57% of rats and BDS activation induced by 1% isoflurane in 81% of rats. These results open new perspectives for the development of clinically significant bedside technologies for EEG-monitoring of OBBB and BDS.

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Editor:
Huang, Xudong
Published in:
Biomolecules  
Vol. 13, No. 11 (02.11.2023)
Volume:
13
No.:
11
Date Issued:
02.11.2023
DOI:
10.3390/biom13111605
Language:
English
Type of Resource:
Text
Keywords:
  1. anesthesia
    Typ
    Schlagwort
  1. machine learning technology
    Typ
    Schlagwort
  1. spectral power analysis
    Typ
    Schlagwort
  1. blood–brain barrier
    Typ
    Schlagwort
  1. brain’s drainage system
    Typ
    Schlagwort
DDC:
610 Medizin und Gesundheit

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