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Beneficial Effects of Sideritis clandestina Extracts and Sideridiol against Amyloid β Toxicity

ORCID
0000-0003-3276-4702
Affiliation
Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece;(A.G.);(Y.P.);(E.P.)
Gioran, Anna;
ORCID
0009-0009-9172-6491
Affiliation
Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece;(A.G.);(Y.P.);(E.P.)
Paikopoulos, Yiorgos;
Affiliation
Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece;(A.G.);(Y.P.);(E.P.)
Panagiotidou, Eleni;
ORCID
0009-0006-8041-8598
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Rizou, Aikaterini E. I.;
ORCID
0000-0002-4988-7066
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Nasi, Georgia I.;
ORCID
0000-0001-9141-4644
Affiliation
Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26504 Patras, Greece;(V.D.D.);(V.M.);(F.N.L.)
Dimaki, Virginia D.;
ORCID
0009-0000-7799-0653
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Vraila, Konstantina D.;
ORCID
0000-0002-0140-423X
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Bezantakou, Dimitra S.;
ORCID
0000-0003-1672-3329
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Spatharas, Panagiotis M.;
ORCID
0000-0002-3533-2182
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Papandreou, Nikos C.;
ORCID
0000-0002-2129-3311
Affiliation
Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26504 Patras, Greece;(V.D.D.);(V.M.);(F.N.L.)
Magafa, Vassiliki;
ORCID
0000-0002-6938-3500
Affiliation
Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26504 Patras, Greece;(V.D.D.);(V.M.);(F.N.L.)
Lamari, Fotini N.;
ORCID
0000-0002-9472-5146
Affiliation
Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece;(A.E.I.R.);(G.I.N.);(K.D.V.);(D.S.B.);(P.M.S.);(N.C.P.);(V.A.I.)
Iconomidou, Vassiliki A.;
ORCID
0000-0002-5867-0862
Affiliation
Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece;(A.G.);(Y.P.);(E.P.)
Chondrogianni, Niki

Alzheimer’s disease (AD) is the most common form of dementia. Given the link between oxidative stress and AD, many studies focus on the identification of natural antioxidants against AD. Although their antioxidant capacity is important, increasing data suggest that additional activities are related to their beneficial effects, including properties against amyloid beta (Aβ) aggregation. Sideritis spp. (mountain tea) extracts possess not only antioxidant activity but also other bioactivities that confer neuroprotection. Although various Sideritis spp. extracts have been extensively studied, there are scarce data on S. clandestina subsp. peloponnesiaca (SCP) phytochemical composition and neuroprotective potential, while nothing is known of the responsible compounds. Given that SCP is a weaker antioxidant compared to other Sideritis spp., here, we investigated its potential beneficial properties against Aβ aggregation. We characterized different SCP extracts and revealed their anti-aggregation activity by taking advantage of established C. elegans AD models. Importantly, we identified two pure compounds, namely, sideridiol and verbascoside, being responsible for the beneficial effects. Furthermore, we have revealed a potential anti-Aβ aggregation mechanism for sideridiol. Our results support the use of mountain tea in the elderly against dementia and demonstrate the activity of sideridiol against Aβ aggregation that could be exploited for drug development.

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Editor:
Núñez, Marco Tulio
Published in:
Antioxidants  
Vol. 13, No. 3 (21.02.2024)
Volume:
13
No.:
3
Date Issued:
21.02.2024
DOI:
10.3390/antiox13030261
Language:
English
Type of Resource:
Text
Keywords:
  1. Sideritis clandestina spp. peloponnesiaca
    Typ
    Schlagwort
  1. Alzheimer’s disease
    Typ
    Schlagwort
  1. Caenorhabditis elegans
    Typ
    Schlagwort
  1. amyloid beta peptide
    Typ
    Schlagwort
  1. protein aggregation
    Typ
    Schlagwort
  1. sideridiol
    Typ
    Schlagwort
  1. verbascoside
    Typ
    Schlagwort
  1. natural antioxidant products
    Typ
    Schlagwort
DDC:
610 Medizin und Gesundheit

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