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A Single Dose of Piperacillin Plus Tazobactam Gel as an Adjunct to Professional Mechanical Plaque Removal (PMPR) in Patients with Peri-Implant Mucositis: A 6-Month Double-Blind Randomized Clinical Trial

ORCID
0000-0002-4837-2693
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Ilyes, Ioana;
Affiliation
Department of Endodontics, Faculty of Dental Medicine, TADERP Research Center, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Boariu, Marius;
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Rusu, Darian;
Affiliation
Department of Periodontology, University of Naples Federico II, 80131 Naples, Italy;
Iorio-Siciliano, Vincenzo;
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Vela, Octavia;
ORCID
0009-0007-7458-4212
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Boia, Simina;
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Kardaras, Georgios;
Affiliation
Department of Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania;
Șurlin, Petra;
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Calniceanu, Horia;
Affiliation
Medical Faculty, University of Leipzig, 04103 Leipzig, Germany;
Jentsch, Holger;
ORCID
0000-0003-4879-3401
Affiliation
Department Basis of Electronics, Faculty of Electronics, Telecommunications and Information Technology, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania;
Lodin, Alexandru;
Affiliation
Department of Periodontology, Faculty of Dental Medicine, Anton Sculean Research Center for Periodontal and Peri-Implant Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania;(I.I.);(D.R.);(O.V.);(S.B.);(G.K.);(H.C.);(S.-I.S.)
Stratul, Stefan-Ioan

Objectives: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. Materials and Methods: The study included 31 patients with peri-implant mucositis (bleeding on probing (BoP) > 1 at at least one site at baseline, absence of peri-implant bone loss compared with a previous radiograph). After randomized assignment to test and control groups, patients received full-mouth supragingival scaling with or without piperacillin plus tazobactam gel. Clinical examination was performed at baseline and after 3 and 6 months, and a microbiological examination was performed at baseline and after 3 months. Results: After six months, both treatment modalities resulted in significant reductions and improvements in clinical parameters at the implant sites. Neither study group achieved a complete resolution of PiM (i.e., BoP ≤ 1 per implant). The number of implants with BoP decreased statistically significantly between subsequent time points ( p < 0.001) in both the test and the control group. Significant BoP differences ( p = 0.039) were observed between groups at 6 months (difference to baseline) following therapy. Conclusions: Within the limitations of the present study, the single use of a slow-release, locally applied antibiotic combination of piperacillin and tazobactam gel, adjunctive to PMPR, showed an improvement in clinical variable of implants diagnosed with PiM. The adjunctive treatment resulted in higher BoP reduction when compared to the control, but no significant differences were observed regarding the changes in other clinical and microbiological parameters.

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Editor:
Velasco-Ortega, Eugenio; Salgado-Peralvo, Angel-Orion; Peña-Cardelles, Juan Francisco
Published in:
Antibiotics  
Vol. 13, No. 3 (17.03.2024)
Volume:
13
No.:
3
Date Issued:
17.03.2024
DOI:
10.3390/antibiotics13030269
Language:
English
Type of Resource:
Text
Keywords:
  1. peri-implant mucositis
    Typ
    Schlagwort
  1. clinical trial
    Typ
    Schlagwort
  1. local antibiotics
    Typ
    Schlagwort
  1. adjuvant therapy
    Typ
    Schlagwort
DDC:
615 Pharmakologie, Therapie

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