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The molecular mechanisms of peptidyl-prolyl cis/trans isomerase Pin1 and its relevance to kidney disease

Affiliation
Department of Nephrology ,Sichuan Provincial People’s Hospital ,University of Electronic Science and Technology of China ,Chengdu ,China
Wu, Shukun;
Affiliation
Department of Nephrology ,Sichuan Provincial People’s Hospital ,University of Electronic Science and Technology of China ,Chengdu ,China
Zou, Yurong;
Affiliation
Key Laboratory of Medical Electrophysiology ,Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province ,Institute of Cardiovascular Research ,Southwest Medical University ,Luzhou ,China
Tan, Xiaoqiu;
Affiliation
Department of Nephrology ,Sichuan Provincial People’s Hospital ,University of Electronic Science and Technology of China ,Chengdu ,China
Yang, Shuang;
Affiliation
Key Laboratory of Medical Electrophysiology ,Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province ,Institute of Cardiovascular Research ,Southwest Medical University ,Luzhou ,China
Chen, Tangting;
Affiliation
Department of Nephrology ,Sichuan Provincial People’s Hospital ,University of Electronic Science and Technology of China ,Chengdu ,China
Zhang, Jiong;
Affiliation
State Key Laboratory for Innovation and Transformation of Luobing Theory ,Key Laboratory of Cardiovascular Remodeling and Function Research ,Chinese Ministry of Education ,Chinese National Health Commission and Chinese Academy of Medical Sciences ,Department of Cardiology ,Qilu Hospital of Shandong University ,Jinan ,China
Xu, Xingli;
Affiliation
Department of Nephrology ,Sichuan Provincial People’s Hospital ,University of Electronic Science and Technology of China ,Chengdu ,China
Wang, Fang;
Affiliation
Department of Emergency Surgery ,Sichuan Provincial People’s Hospital ,University of Electronic Science and Technology of China ,Chengdu ,China
Li, Wei

Pin1 is a member of the peptidyl-prolyl cis/trans isomerase subfamily and is widely expressed in various cell types and tissues. Alterations in Pin1 expression levels play pivotal roles in both physiological processes and multiple pathological conditions, especially in the onset and progression of kidney diseases. Herein, we present an overview of the role of Pin1 in the regulation of fibrosis, oxidative stress, and autophagy. It plays a significant role in various kidney diseases including Renal I/R injury, chronic kidney disease with secondary hyperparathyroidism, diabetic nephropathy, renal fibrosis, and renal cell carcinoma. The representative therapeutic agent Juglone has emerged as a potential treatment for inhibiting Pin1 activity and mitigating kidney disease. Understanding the role of Pin1 in kidney diseases is expected to provide new insights into innovative therapeutic interventions and strategies. Consequently, this review delves into the molecular mechanisms of Pin1 and its relevance in kidney disease, paving the way for novel therapeutic approaches.

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License Holder: Copyright © 2024 Wu, Zou, Tan, Yang, Chen, Zhang, Xu, Wang and Li.

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