Feedback
  • Article / Essay
  • Effects and Stress-Relieving Mechanisms of Dark Tea Polysaccharide in Human…

Effects and Stress-Relieving Mechanisms of Dark Tea Polysaccharide in Human HaCaT Keratinocytes and SZ95 Sebocytes

Affiliation
Syoung Cosmetics Manufacturing Co., Ltd., Changsha 410000, China;(C.G.);(J.F.);(J.C.);(T.Z.)
Gao, Chang;
Affiliation
Syoung Cosmetics Manufacturing Co., Ltd., Changsha 410000, China;(C.G.);(J.F.);(J.C.);(T.Z.)
Fu, Jiafeng;
Affiliation
Syoung Cosmetics Manufacturing Co., Ltd., Changsha 410000, China;(C.G.);(J.F.);(J.C.);(T.Z.)
Cui, Junyi;
Affiliation
Syoung Cosmetics Manufacturing Co., Ltd., Changsha 410000, China;(C.G.);(J.F.);(J.C.);(T.Z.)
Zhang, Tingzhi;
ORCID
0000-0003-1646-2608
Affiliation
Departments of Dermatology, Venereology, Allergology and Immunology, Staedtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Auenweg 38, 06847 Dessau, Germany
Zouboulis, Christos C.;
Affiliation
School of Chemistry and Material Engineering, Jiangnan University, Wuxi 214122, China;
Wang, Jing;
Affiliation
Syoung Cosmetics Manufacturing Co., Ltd., Changsha 410000, China;(C.G.);(J.F.);(J.C.);(T.Z.)
Yan, Shaowei

A new skincare application scenario for dark tea, a unique and post-fermented tea popular in the health food industry, was developed in this paper. The effects of dark tea polysaccharide (DTP) on stress-induced skin problems and its mechanism of action were investigated by modeling cortisone-induced stress injury in human HaCaT keratinocytes and SZ95 sebaceous gland cells. The results showed a reduced cortisol conversion induced by cortisone under the action of DTP with a concentration of 200 μg/mL, probably by inhibiting the expression of the HSD11B1 enzyme. DTP was also able to suppress the cortisone-induced elevation of lipid levels in SZ95 sebocytes at this concentration. In addition, the composition and structure of DTP were verified by ultrafiltration, ultraviolet-visible spectrophotometry (UV-VIS), high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD) and infrared spectroscopy. In brief, DTP has a unique and significant stress-relieving effect, which provides new ideas for the development of new ingredients for the skin care industry.

Preview

Category

Editor:
Barrajón-Catalán, Enrique
Published in:
Molecules  
Vol. 28, No. 16 (18.08.2023)
Volume:
28
No.:
16
Date Issued:
18.08.2023
DOI:
10.3390/molecules28166128
Language:
English
Type of Resource:
Text
Keywords:
stress; dark tea polysaccharide; cortisol; sebum
DDC:
610 Medizin und Gesundheit

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:
open graphic

Rights

License Holder: © 2023 by the authors.

Use and reproduction: