Feedback

Reduced Lipid Peroxidation Predicts Unfavorable Prognosis in Hepatocellular Carcinoma, but Not Intrahepatic Cholangiocarcinoma

ORCID
0000-0001-9910-2186
Affiliation
Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(T.S.G.);(H.R.W.);(M.S.);(W.R.);(D.A.R.)
Gerber, Tiemo Sven;
Affiliation
Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(T.S.G.);(H.R.W.);(M.S.);(W.R.);(D.A.R.)
Witzel, Hagen Roland;
Affiliation
Department of Internal Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(A.W.);(P.R.G.)
Weinmann, Arndt;
ORCID
0000-0001-6090-2530
Affiliation
Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(F.B.);(H.L.)
Bartsch, Fabian;
Affiliation
Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(T.S.G.);(H.R.W.);(M.S.);(W.R.);(D.A.R.)
Schindeldecker, Mario;
ORCID
0000-0003-1967-0621
Affiliation
Department of Internal Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(A.W.);(P.R.G.)
Galle, Peter R.;
Affiliation
Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(F.B.);(H.L.)
Lang, Hauke;
Affiliation
Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(T.S.G.);(H.R.W.);(M.S.);(W.R.);(D.A.R.)
Roth, Wilfried;
Affiliation
Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(T.S.G.);(H.R.W.);(M.S.);(W.R.);(D.A.R.)
Ridder, Dirk Andreas;
ORCID
0000-0002-4857-1561
Affiliation
Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany;(T.S.G.);(H.R.W.);(M.S.);(W.R.);(D.A.R.)
Straub, Beate Katharina

Primary liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), remains a significant contributor to cancer-related mortality worldwide. Oxidative stress and lipid peroxidation play a key role in chronic liver diseases and have been shown to be pivotal for tumor initiation and progression. 4-hydroxy-nonenal (4-HNE), one of the major mediators of oxidative stress and a well-established biomarker for lipid peroxidation, can act as a signal transducer, inducing inflammation and exerting carcinogenic effects. However, the role of 4-HNE in primary liver cancer remains poorly explored. In this study, we investigated 4-HNE levels in 797 liver carcinomas, including 561 HCC and 236 iCCA, by immunohistochemistry. We then correlated 4-HNE levels with comprehensive clinical data and survival outcomes. In HCC, lower expression levels of 4-HNE were associated with vascular invasion, a high tumor grade, a macrotrabecular-massive HCC subtype, and poor overall survival. Concerning iCCA, large duct iCCA showed significantly higher 4-HNE levels when compared to small duct iCCA. Yet, in iCCA, 4-HNE levels did not correlate with known prognostic parameters or survival outcomes. To conclude, in HCC but not in iCCA, low amounts of 4-HNE predict unfavorable survival outcomes and are associated with aggressive tumor behavior. These findings provide insights into the role of 4-HNE in liver cancer progression and may enable novel therapeutic strategies.

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

License Holder: © 2023 by the authors.

Use and reproduction: