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Redefining the polypill: pros and cons in cardiovascular precision medicine

Affiliation
Department of Biochemistry ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Birla, Siddharth;
Affiliation
Department of Medical Genetics ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Angural, Arshia;
Affiliation
Department of Medical Genetics ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Madathumchalil, Arya;
Affiliation
Department of Medical Genetics ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Shende, Ritika V.;
Affiliation
Department of Medical Genetics ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Shastry, Sharvani V.;
Affiliation
Department of Cardiology ,JSS Medical College and Hospital ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Mahadevappa, Manjappa;
Affiliation
Department of Cardiology ,JSS Medical College and Hospital ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Shambhu, Sunil Kumar;
Affiliation
Department of Biochemistry ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Vishwanath, Prashant;
Affiliation
Department of Biochemistry ,JSS Medical College ,JSS Academy of Higher Education and Research ,Sri Shivarathreeshwara Nagara ,Mysuru ,Karnataka ,India
Prashant, Akila

Polypill is a multi-drug formulation in a single pill intended to simplify the drug regimen and reduce medication-induced adverse effects. The most common multidrug combinations in a polypill are used to treat cardiovascular diseases and are targeted against key modifiable risk factors such as hypertension and hyperlipidemia. These contain blood-pressure lowering agents, statins, and anti-platelet agents usually in a fixed dose. Polypills can be an affordable therapeutic intervention for treating high-risk patients, as these are proven to increase patients’ adherence to medication and improve clinical outcomes. Over the previous years, randomized clinical trials of several polypills have yielded contradictory findings, raising skepticism regarding their widespread use in primary disease prevention. Here, we have reviewed the concept of polypills, the evidence-based strengths, the limitations of this polypharmacy intervention strategy, and discussed future directions for their use in the primary and secondary preventive management of cardiovascular diseases and associated risk factors.

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License Holder: Copyright © 2023 Birla, Angural, Madathumchalil, Shende, Shastry, Mahadevappa, Shambhu, Vishwanath and Prashant.

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