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Recent advances in the study of anesthesia-and analgesia-related mechanisms of S-ketamine

Affiliation
The First Clinical Medical College of Gannan Medical University ,Ganzhou ,China
Zhou, Jian-shun;
Affiliation
The First Clinical Medical College of Gannan Medical University ,Ganzhou ,China
Peng, Guan-fa;
Affiliation
Department of Anesthesiology ,First Affiliated Hospital of Gannan Medical University ,Ganzhou ,China
Liang, Wei-dong;
Affiliation
The First Clinical Medical College of Gannan Medical University ,Ganzhou ,China
Chen, Zhen;
Affiliation
The First Clinical Medical College of Gannan Medical University ,Ganzhou ,China
Liu, Ying-ying;
Affiliation
The First Clinical Medical College of Gannan Medical University ,Ganzhou ,China
Wang, Bing-yu;
Affiliation
The First Clinical Medical College of Gannan Medical University ,Ganzhou ,China
Guo, Ming-ling;
Affiliation
Department of Anesthesiology ,First Affiliated Hospital of Gannan Medical University ,Ganzhou ,China
Deng, Yun-ling;
Affiliation
Department of Anesthesiology ,First Affiliated Hospital of Gannan Medical University ,Ganzhou ,China
Ye, Jun-ming;
Affiliation
Department of Anesthesiology ,First Affiliated Hospital of Gannan Medical University ,Ganzhou ,China
Zhong, Mao-lin;
Affiliation
Department of Anesthesiology ,First Affiliated Hospital of Gannan Medical University ,Ganzhou ,China
Wang, Li-feng

Ketamine is a racemic mixture of equal amounts of R-ketamine and S-ketamine and is well known to anesthesiologists for its unique dissociative anesthetic properties. The pharmacological properties of ketamine, namely, its sympathetic excitation, mild respiratory depression, and potent analgesia, are still highly valued in its use as an anesthetic for some patients. In particular, since its advent, S-ketamine has been widely used as an anesthetic in many countries due to its increased affinity for NMDA receptors and its enhanced anesthetic and analgesic effects. However, the anesthetic and analgesic mechanisms of S-ketamine are not fully understood. In addition to antagonizing NMDA receptors, a variety of other receptors or channels may be involved, but there are no relevant mechanistic summaries in the literature. Therefore, the purpose of this paper is to review the mechanisms of action of S-ketamine on relevant receptors and systems in the body that result in its pharmacological properties, such as anesthesia and analgesia, with the aim of providing a reference for its clinical applications and research.

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License Holder: Copyright © 2023 Zhou, Peng, Liang, Chen, Liu, Wang, Guo, Deng, Ye, Zhong and Wang.

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