Feedback

Intraoperative slow-release dexamethasone intravitreal implant (Ozurdex) in epiretinal membrane peeling surgery: a prospective randomized controlled trial

Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Li, Siying;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Zeng, Qiaozhu;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Zhu, Li;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Liu, Wenbo;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Li, Yujing;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Li, Jiarui;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Li, Xiaoxin;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Zhao, Mingwei;
Affiliation
Department of Ophthalmology ,Peking University People’s Hospital ,Eye Diseases and Optometry Institute ,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases ,College of Optometry ,Peking University Health Science Center ,Beijing ,China
Qu, Jinfeng

Purpose : This study aimed to determine the efficacy of the dexamethasone (DEX) intravitreal implant for the regression of macular edema and the improvement of best-corrected visual acuity (BCVA) after the removal of idiopathic epiretinal membrane (ERM). Methods : This prospective randomized controlled trial recruited 81 patients with idiopathic ERM. These patients all underwent 25-gauge pars plana vitrectomy combined with ERM and internal limiting membrane peeling surgery. Among them, 41 eyes in the DEX group received additional DEX implants and 40 in the non-DEX group did not. Outcomes including central retinal thickness (CRT), BCVA, and intraocular pressure were measured 1 and 3 months after surgery. Results : The DEX group had thinner CRTs compared to the non-DEX group at 1 month postoperatively ( p <0.05), but did not differ significantly at the 1-week and 3-month follow-up visits ( p = 0.109 and p = 0.417, respectively). There were no statistical differences with respect to BCVA ( p = 0.499, 0.309, 0.246, and 0.517, respectively) and intraocular pressure ( p = 0.556, 0.639, 0.741, and 0.517, respectively) between the two groups at each point of follow-up visits. Conclusion : DEX accelerated the reduction of CRT at 1 month after surgery. However, no evidence of further anatomical (CRT) or functional (BCVA) benefits using DEX was observed at 3 months. Clinical Trial Registration: https://clinicaltrials.gov/ , identifier NCT05416827 .

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

License Holder: Copyright © 2023 Li, Zeng, Zhu, Liu, Li, Li, Li, Zhao and Qu.

Use and reproduction: