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How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

ORCID
0000-0002-7148-2559
Affiliation
Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy;(L.M.C.);(M.M.);(E.T.)
Azzini, Anna Maria;
ORCID
0000-0003-2537-5418
Affiliation
Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy;(L.M.C.);(M.M.);(E.T.)
Canziani, Lorenzo Maria;
ORCID
0000-0001-9364-6983
Affiliation
Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy;(L.M.C.);(M.M.);(E.T.)
Davis, Ruth Joanna;
ORCID
0000-0002-2342-5867
Affiliation
Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy;(L.M.C.);(M.M.);(E.T.)
Mirandola, Massimo;
ORCID
0000-0002-7642-1835
Affiliation
Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), 80802 Munich, Germany;
Hoelscher, Michael;
Affiliation
Centre de Recherche en Epidemiologie et Sante des Population, Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris-Saclay, 94270 Le Kremlin-Bicêtre, France;
Meyer, Laurence;
Affiliation
INSERM, IAME UMR 1137, Universite Paris Cite, 75018 Paris, France;
Laouénan, Cédric;
Affiliation
Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy;
Giannella, Maddalena;
ORCID
0000-0001-6732-9001
Affiliation
Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen Macarena and Department of Medicine, Biomedicines Institute of Sevilla-CSIC, University of Sevilla, 41004 Sevilla, Spain;
Rodríguez-Baño, Jesús;
ORCID
0000-0002-3811-2791
Affiliation
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy;
Boffetta, Paolo;
Affiliation
National Institute of Public Health, 050463 Bucharest, Romania;
Mates, Dana;
Affiliation
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, 2000 Antwerp, Belgium;
Malhotra-Kumar, Surbhi;
ORCID
0000-0001-7202-9994
Affiliation
Supercomputing Applications and Innovation Department, Cineca Consorzio Interuniversitario, 40033 Bologna, Italy;
Scipione, Gabriella;
ORCID
0000-0001-6798-8533
Affiliation
Berlin Institute of Health at Charite, Universitätsmedizin Berlin, 10117 Berlin, Germany;(C.S.);(E.R.)
Stellmach, Caroline;
Affiliation
Berlin Institute of Health at Charite, Universitätsmedizin Berlin, 10117 Berlin, Germany;(C.S.);(E.R.)
Rinaldi, Eugenia;
Affiliation
Life and Medical Sciences Institute, University of Bonn, 53113 Bonn, Germany;
Hasenauer, Jan;
Affiliation
Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy;(L.M.C.);(M.M.);(E.T.)
Tacconelli, Evelina

ORCHESTRA (“Connecting European Cohorts to Increase Common and Effective Response To SARS-CoV-2 Pandemic”) is an EU-funded project which aims to help rapidly advance the knowledge related to the prevention of the SARS-CoV-2 infection and the management of COVID-19 and its long-term sequelae. Here, we describe the early results of this project, focusing on the strengths of multiple, international, historical and prospective cohort studies and highlighting those results which are of potential relevance for vaccination strategies, such as the necessity of a vaccine booster dose after a primary vaccination course in hematologic cancer patients and in solid organ transplant recipients to elicit a higher antibody titer, and the protective effect of vaccination on severe COVID-19 clinical manifestation and on the emergence of post-COVID-19 conditions. Valuable data regarding epidemiological variations, risk factors of SARS-CoV-2 infection and its sequelae, and vaccination efficacy in different subpopulations can support further defining public health vaccination policies.

Category

Editor:
Tripp, Ralph A.
Published in:
Vaccines  
Vol. 11, No. 8 (14.08.2023)
Volume:
11
No.:
8
Date Issued:
14.08.2023
DOI:
10.3390/vaccines11081361
Language:
English
Type of Resource:
Text
Keywords:
COVID-19; cohort study; public health; vaccination; data harmonization; fragile population; healthcare workers
Subject of DNB:
610 Medical sciences Medicine
DDC:
615 Pharmakologie, Therapie

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License Holder: © 2023 by the authors.

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