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Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials

Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Al-Rubaiai, Fatma;
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Al-Shariqi, Zakiya Zahran;
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Al-Shabibi, Khalsa S.;
ORCID
0000-0002-1567-2999
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Husband, John;
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Al-Hattali, Asmaa M.;
Affiliation
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, D-72076 Tübingen, Germany(S.L.)
Goettert, Marcia;
ORCID
0000-0001-6952-1486
Affiliation
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls Universität Tübingen, D-72076 Tübingen, Germany(S.L.)
Laufer, Stefan;
ORCID
0000-0002-9659-8419
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Baqi, Younis;
ORCID
0000-0003-1839-184X
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Hassan, Syed Imran;
ORCID
0000-0003-3289-112X
Affiliation
Department of Chemistry, College of Science, Sultan Qaboos University, Al Khod, P.O. Box 36, Muscat 123, Oman;(F.A.-R.);(J.H.);(Y.B.)
Fatope, Majekodunmi O.

Maytenus dhofarensis Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of M. dhofarensis afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid ( 1 ), lupanyl myristoate ( 2 ) and lignanolactone ( 3 ). Compounds ( 1 – 3 ) are new isolates from M. dhofarensis . The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds 1 and 3 were deduced from density function theory (DFT) calculations and NMR experiments. Compound 1 was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 µM test concentration. Compound 3 inhibited the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.

Category

Editor:
Gonçalves, Sandra; Romano, Anabela
Published in:
Molecules  
Vol. 28, No. 16 (15.08.2023)
Volume:
28
No.:
16
Date Issued:
15.08.2023
DOI:
10.3390/molecules28166077
Language:
English
Type of Resource:
Text
Keywords:
Maytenus dhofarensis; secondary metabolites; biological activities
Subject of DNB:
610 Medical sciences Medicine
DDC:
615 Pharmakologie, Therapie

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