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Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy—A Pilot Study

Affiliation
Department of Urology, Rheinland Klinikum Neuss, 41464 Neuss, Germany;
Barski, Dimitri;
ORCID
0000-0001-5107-3523
Affiliation
Department for Urology and Pediatric Urology, University Medical Center of Johannes Gutenberg, 55131 Mainz, Germany
Tsaur, Igor;
Affiliation
Institute of Surgical Research, University of Szeged, 6720 Szeged, Hungary
Boros, Mihaly;
ORCID
0000-0002-4395-6411
Affiliation
DIZG—Deutsches Institut für Zell-und Gewebeersatz gGmbH, 12555 Berlin, Germany
Brune, Jan;
Affiliation
Department of Urology, Rheinland Klinikum Neuss, 41464 Neuss, Germany;
Otto, Thomas

Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of-concept trial of 14 patients undergoing radical prostatectomy (RP). The patients were followed up at a median of 13 months, and the continence and potency rates were reported. Early recovery of continence was found after three months. No effect on potency was detected. The findings indicate the feasibility of this tissue-engineering strategy, and justify prospective comparative studies.

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