The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Silva, Jéssica Manoelli Costa; Teixeira, Eliel Barbosa; Mourão, Ronald Matheus da Silva; Ferraz, Rafaella Sousa; Moreira, Fabiano Cordeiro; Assumpção, Paulo Pimentel de; Calcagno, Danielle Queiroz

doi:10.3389/fphar.2023.1237723

Article / Essay Mon Aug 21 2023 CC BY 4.0

published

The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Silva, Jéssica Manoelli Costa ; Teixeira, Eliel Barbosa ; Mourão, Ronald Matheus da Silva ; Ferraz, Rafaella Sousa ; Moreira, Fabiano Cordeiro ; Assumpção, Paulo Pimentel de ; Calcagno, Danielle Queiroz

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.