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Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives

Affiliation
Department of Clinical Biochemistry ,School of Pharmacy and Pharmaceutical Sciences ,Isfahan University of Medical Sciences ,Isfahan ,Iran
Mafi, Alireza;
Affiliation
School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Rismanchi, Hamidreza;
Affiliation
Department of Pharmacology ,School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Gholinezhad, Yasaman;
Affiliation
School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Mohammadi, Mohaddese Malek;
Affiliation
School of Medicine ,Bushehr University of Medical Sciences ,Bushehr ,Iran
Mousavi, Vahide;
Affiliation
School of Medicine ,Babol University of Medical Sciences ,Babol ,Mazandaran ,Iran
Hosseini, Seyed Ali;
Affiliation
Department of Clinical Biochemistry ,School of Pharmacy and Pharmaceutical Sciences ,Isfahan University of Medical Sciences ,Isfahan ,Iran
Milasi, Yaser Eshaghi;
Affiliation
Department of Cell Systems and Anatomy ,UT Health Long School of Medicine ,San Antonio ,TX ,United States
Reiter, Russel J.;
Affiliation
Department of Immunology ,School of Medicine ,Isfahan University of Medical Sciences ,Isfahan ,Iran
Ghezelbash, Behrooz;
Affiliation
Department of Pharmacology ,School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Rezaee, Malihe;
Affiliation
School of Medicine ,Kashan University of Medical Sciences ,Kashan ,Iran
Sheida, Amirhossein;
Affiliation
School of Medicine ,Kashan University of Medical Sciences ,Kashan ,Iran
Zarepour, Fatemeh;
Affiliation
Research Center for Biochemistry and Nutrition in Metabolic Diseases ,Institute for Basic Sciences ,Kashan University of Medical Sciences ,Kashan ,Iran
Asemi, Zatollah;
Affiliation
Department of Epidemiology and Biostatistics ,School of Public Health ,Tehran University of Medical Sciences ,Tehran ,Iran
Mansournia, Mohammad Ali;
Affiliation
Research Center for Biochemistry and Nutrition in Metabolic Diseases ,Institute for Basic Sciences ,Kashan University of Medical Sciences ,Kashan ,Iran
Mirzaei, Hamed

Leukaemia is a dangerous malignancy that causes thousands of deaths every year throughout the world. The rate of morbidity and mortality is significant despite many advancements in therapy strategies for affected individuals. Most antitumour medications used now in clinical oncology use apoptotic signalling pathways to induce cancer cell death. Accumulated data have shown a direct correlation between inducing apoptosis in cancer cells with higher tumour regression and survival. Until now, the efficacy of melatonin as a powerful antitumour agent has been firmly established. A change in melatonin concentrations has been reported in multiple tumours such as endometrial, hematopoietic, and breast cancers. Findings show that melatonin’s anticancer properties, such as its prooxidation function and ability to promote apoptosis, indicate the possibility of utilizing this natural substance as a promising agent in innovative cancer therapy approaches. Melatonin stimulates cell apoptosis via the regulation of many apoptosis facilitators, including mitochondria, cytochrome c, Bcl-2, production of reactive oxygen species, and apoptosis receptors. This paper aimed to further assess the anticancer effects of melatonin through the apoptotic pathway, considering the role that cellular apoptosis plays in the pathogenesis of cancer. The effect of melatonin may mean that it is appropriate for use as an adjuvant, along with other therapeutic approaches such as radiotherapy and chemotherapy.

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License Holder: Copyright © 2023 Mafi, Rismanchi, Gholinezhad, Mohammadi, Mousavi, Hosseini, Milasi, Reiter, Ghezelbash, Rezaee, Sheida, Zarepour, Asemi, Mansournia and Mirzaei.

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