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Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent

Affiliation
High Altitude Plant Physiology Research Centre (HAPPRC) ,HNB. Garhwal University (A Central University) ,Srinagar Garhwal ,Uttarakhand ,India
Trivedi, Vijay Laxmi;
Affiliation
Regional Centre for Organic and Natural Farming ,Ghaziabad ,Uttar Pradesh ,India
Soni, Ruchi;
Affiliation
Institute for Integrated Natural Sciences ,University of Koblenz ,Koblenz ,Germany
Dhyani, Praveen;
Affiliation
Department of Biotechnology ,Kumaun University ,Bhimtal ,Uttarakhand ,India
Sati, Priyanka;
Affiliation
Laboratory of Neurophysiology ,Department of Biology ,University of the Balearic Islands ,Palma de Mallorca ,Spain
Tejada, Silvia;
Affiliation
Laboratory of Neurophysiology ,Department of Biology ,University of the Balearic Islands ,Palma de Mallorca ,Spain
Sureda, Antoni;
Affiliation
Aromatic Plant Research Center ,Lehi ,UT ,United States
Setzer, William N.;
Affiliation
Department of Food Science ,Faculty of Food Science and Technology ,Universiti Putra Malaysia ,Selangor ,Malaysia
Faizal Abdull Razis, Ahmad;
Affiliation
Natural Medicines and Products Research Laboratory ,Institute of Bioscience ,Universiti Putra Malaysia ,Selangor ,Malaysia
Modu, Babagana;
Affiliation
University of Life Sciences “King Mihai I” From Timisoara ,Timis ,Romania
Butnariu, Monica;
Affiliation
Facultad de Medicina ,Universidad del Azuay ,Cuenca ,Ecuador
Sharifi-Rad, Javad

With the advent of highly effective plant-based medications with few or no side effects, the use of phytomedicines against complex diseases such as cancer is becoming more widespread. The broadly recognized pentacyclic triterpenes known as boswellic acids (BAs) are derived from the oleogum resin, or frankincense, extracted from the plant species of the genus Boswellia . The frankincense mixture contains various BA types, each having a different potential and helping treat certain cancers. This review focuses on details regarding the traits of the BAs, their roles as anti-cancer agents, the mechanism underlying their activities, and the function of their semi-synthetic derivatives in managing and treating certain cancers. The review also explores the biological sources of BAs, how they are conserved, and how biotechnology might help preserve and improve in vitro BA production. The review concludes that the BAs and their semi-synthetic derivatives are effective against a broad spectrum of cancer cell lines. The detailed information in the review can be helpful for researchers to gain more information about BAs and BA-based medications for efficient and cost-effective cancer treatments.

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License Holder: Copyright © 2023 Trivedi, Soni, Dhyani, Sati, Tejada, Sureda, Setzer, Faizal Abdull Razis, Modu, Butnariu and Sharifi-Rad.

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