Feedback

Case report: Lung transplantation for treatment of paraquat intoxication: timing of transplantation

Affiliation
Department of Surgery ,The First Hospital of Jilin University ,Changchun ,China
Li, Congcong;
Affiliation
Department of Thoracic Surgery ,The First Hospital of Jilin University ,Changchun ,China
Cai, Hongfei;
Affiliation
Department of Thoracic Surgery ,The First Hospital of Jilin University ,Changchun ,China
Meng, Fanyu;
Affiliation
Department of Surgery ,The First Hospital of Jilin University ,Changchun ,China
Meng, Fanjie;
Affiliation
Department of Thoracic Surgery ,The First Hospital of Jilin University ,Changchun ,China
Tang, Ze;
Affiliation
Department of Respiratory and Critical Care Medicine ,The First Hospital of Jilin University ,Changchun ,China
Tang, Ying;
Affiliation
Department of Critical Medicine ,The First Hospital of Jilin University ,Changchun ,China
Chen, Ying;
Affiliation
Department of Thoracic Surgery ,The First Hospital of Jilin University ,Changchun ,China
Cui, Youbin;
Affiliation
Department of Thoracic Surgery ,Organ Transplantation Center ,The First Hospital of Jilin University ,Changchun ,China
Li, Yang

Objective: To analyze the optimal timing of lung transplantation and summarize postoperative complications and their management after paraquat poisoning. Methods: Here, we present the clinical course of a 17-year-old boy with paraquat poisoning, in whom bilateral lung transplantation (LT) was performed. We reviewed the eight previously published articles relevant to LT after paraquat poisoning to summarize the therapeutic strategy. Results: A 17-year-old boy was admitted to the hospital after ingestion of 30–50 mL 25% paraquat. Mechanical ventilation was initiated on the 25th day after intoxication. Venovenous extracorporeal membrane oxygenation was initiated on the 26th day. Sequential bilateral LT was performed on the 27th day. Several complex postoperative complications occurred and the patient was discharged on the 50th day postoperatively. Eight case reports were included in the literature review, including 11 patients with paraquat poisoning undergoing LT. Three patients died due to paraquat poisoning leading to fibrosis in the transplanted lungs or postoperative complications. Eight patients survived during follow-up. Conclusion: LT after herbicide poisoning should be planned when hepatorenal function starts to recover, and waiting for complete recovery is unnecessary. Prevention of infection before surgery is important to reduce the incidence of postoperative infection. Complex perioperative complications caused by the herbicide itself or the late timing of transplantation can be successfully managed by a multidisciplinary team.

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

License Holder: Copyright © 2023 Li, Cai, Meng, Meng, Tang, Tang, Chen, Cui and Li.

Use and reproduction: