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To explore the effect of kaempferol on non-small cell lung cancer based on network pharmacology and molecular docking

Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Zhang, Junli;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Liu, Xiangqi;
Affiliation
Experimental Center ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Zhang, Guoying;
Affiliation
Department of Scientific Research ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Wu, Junling;
Affiliation
Shandong Tai’an Central Hospital ,Tai’an ,China
Liu, Zhongfang;
Affiliation
Experimental Center ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Liu, Chuanguo;
Affiliation
Daiyue District Maternal and Child Health Hospital ,Tai’an ,Shandong ,China
Wang, Hui;
Affiliation
School of Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Miao, Shuxin;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Deng, Lei;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Cao, Kuan;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Shang, Miwei;
Affiliation
Innovative Institute of Chinese Medicine and Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Zhu, Qingjun;
Affiliation
School of Pharmacy ,Shandong University of Traditional Chinese Medicine ,Jinan ,China
Sun, Peng

Non-small cell lung cancer (NSCLC) is a common pathological type of lung cancer, which has a serious impact on human life, health, psychology and life. At present, chemotherapy, targeted therapy and other methods commonly used in clinic are prone to drug resistance and toxic side effects. Natural extracts of traditional Chinese medicine (TCM) have attracted wide attention in cancer treatment because of their small toxic and side effects. Kaempferol is a flavonoid from natural plants, which has been proved to have anticancer properties in many cancers such as lung cancer, but the exact molecular mechanism is still unclear. Therefore, on the basis of in vitro experiments, we used network pharmacology and molecular docking methods to study the potential mechanism of kaempferol in the treatment of non-small cell lung cancer. The target of kaempferol was obtained from the public database (PharmMapper, Swiss target prediction), and the target of non-small cell lung cancer was obtained from the disease database (Genecards and TTD). At the same time, we collected gene chips GSE32863 and GSE75037 in conjunction with GEO database to obtain differential genes. By drawing Venn diagram, we get the intersection target of kaempferol and NSCLC. Through enrichment analysis, PI3K/AKT is identified as the possible key signal pathway. PIK3R1, AKT1, EGFR and IGF1R were selected as key targets by topological analysis and molecular docking, and the four key genes were further verified by analyzing the gene and protein expression of key targets. These findings provide a direction for further research of kaempferol in the treatment of NSCLC.

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License Holder: Copyright © 2023 Zhang, Liu, Zhang, Wu, Liu, Liu, Wang, Miao, Deng, Cao, Shang, Zhu and Sun.

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