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FAIR data management: what does it mean for drug discovery?

Affiliation
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) ,Hamburg ,Germany
Gadiya, Yojana;
Affiliation
Vital-IT Group ,SIB Swiss Institute of Bioinformatics ,Lausanne ,Switzerland
Ioannidis, Vassilios;
Affiliation
Bayer AG ,Business Development & Licensing & OI ,Pharmaceuticals ,Berlin ,Germany
Henderson, David;
Affiliation
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP) ,Hamburg ,Germany
Gribbon, Philip;
Affiliation
Oxford e-Research Centre ,Department of Engineering Science ,University of Oxford ,Oxford ,United Kingdom
Rocca-Serra, Philippe;
Affiliation
Luxembourg Centre for Systems Biomedicine ,ELIXIR Luxembourg ,University of Luxembourg ,Esch-sur-Alzette ,Luxembourg
Satagopam, Venkata;
Affiliation
Oxford e-Research Centre ,Department of Engineering Science ,University of Oxford ,Oxford ,United Kingdom
Sansone, Susanna-Assunta;
Affiliation
Luxembourg Centre for Systems Biomedicine ,ELIXIR Luxembourg ,University of Luxembourg ,Esch-sur-Alzette ,Luxembourg
Gu, Wei

The drug discovery community faces high costs in bringing safe and effective medicines to market, in part due to the rising volume and complexity of data which must be generated during the research and development process. Fully utilising these expensively created experimental and computational data resources has become a key aim of scientists due to the clear imperative to leverage the power of artificial intelligence (AI) and machine learning-based analyses to solve the complex problems inherent in drug discovery. In turn, AI methods heavily rely on the quantity, quality, consistency, and scope of underlying training data. While pre-existing preclinical and clinical data cannot fully replace the need for de novo data generation in a project, having access to relevant historical data represents a valuable asset, as its reuse can reduce the need to perform similar experiments, therefore avoiding a “reinventing the wheel” scenario. Unfortunately, most suitable data resources are often archived within institutes, companies, or individual research groups and hence unavailable to the wider community. Hence, enabling the data to be Findable, Accessible, Interoperable, and Reusable (FAIR) is crucial for the wider community of drug discovery and development scientists to learn from the work performed and utilise the findings to enhance comprehension of their own research outcomes. In this mini-review, we elucidate the utility of FAIR data management across the drug discovery pipeline and assess the impact such FAIR data has made on the drug development process.

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License Holder: Copyright © 2023 Gadiya, Ioannidis, Henderson, Gribbon, Rocca-Serra, Satagopam, Sansone and Gu.

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