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Bronchoscopic instillation of amphotericin B is a safe and effective measure to treat pulmonary mycosis

Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Yang, Lei;
Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Yang, Changqing;
Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Wan, Nansheng;
Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Xie, Wei;
Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Tian, Yu;
Affiliation
Hunan Chest Hospital ,Changsha ,Hunan ,China
Xiao, Yangbao;
Affiliation
Hunan Chest Hospital ,Changsha ,Hunan ,China
Luo, Li;
Affiliation
Department of Respiratory Therapy ,Sir Run Run Shaw Hospital ,Hangzhou ,Zhejiang ,China
Chen, Enguo;
Affiliation
Department of Respiratory Therapy ,Sir Run Run Shaw Hospital ,Hangzhou ,Zhejiang ,China
Zhang, Jisong;
Affiliation
Shandong Public Health Clinical Center ,Jinan ,Shandong ,China
Wang, Xiaoping;
Affiliation
Shandong Public Health Clinical Center ,Jinan ,Shandong ,China
Xu, Li;
Affiliation
Shandong Provincial Hospital ,Jinan ,Shandong ,China
Wang, Xingguang;
Affiliation
Emergency General Hospital ,Beijing ,China
Zhou, Yunzhi;
Affiliation
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital ,Chengdu ,Sichuan ,China
Guo, Lu;
Affiliation
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital ,Chengdu ,Sichuan ,China
Zou, Jun;
Affiliation
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital ,Chengdu ,Sichuan ,China
Liu, Xingren;
Affiliation
Hebei Provincial Shenzhou Hospital ,Hengshui ,Hebei ,China
Wei, Xuguang;
Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Wang, Yubao;
Affiliation
Department of Respiratory and Critical Care Medicine ,Tianjin Medical University General Hospital ,Tianjin ,China
Feng, Jing

Background and objectives: In recent years, there has been a significant increase in the prevalence of pulmonary mycosis disease, and its mortality has increased. There are very few studies on treating pulmonary mycosiss with bronchoscopic instillation of amphotericin B. This study investigated the clinical efficacy and safety of bronchoscopic instillation of amphotericin B for treating pulmonary mycosiss. Methods: This was a multi-centre, retrospective clinical study of 80 patients with pulmonary mycosiss who were treated with bronchoscopic instillation of amphotericin B. The efficacy and safety of this treatment were evaluated. Results: Eighty patients were included {51 males; mean [standard deviation (SD)] age, 46 (15.9) years}. The most common underlying cause was haematological malignancy (73.75%). The mean number of bronchoscopic instillations of amphotericin B was 2.4 (SD 1.5). In terms of treatment success, 58 (72.5%) patients achieved complete or partial changes on imaging after treatment. A total of 62 (77.5%) patients achieved complete or partial changes on imaging and/or local limitation of the mycosis infection. Seventy-six (95%) patients achieved complete or partial changes on imaging and/or local limitation of mycosis infection and/or an immunotherapy time window. The efficacy rates for treatment of Aspergillus and Mucor infections in terms of the three treatment success criteria described above were 73.81% vs. 63.64%, 80.95% vs. 72.73%, and 92.86% vs. 90.91%, respectively. Conclusion: Bronchoscopic instillation of amphotericin B is safe and effective for treatment of pulmonary mycosiss.

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License Holder: Copyright © 2023 Yang, Yang, Wan, Xie, Tian, Xiao, Luo, Chen, Zhang, Wang, Xu, Wang, Zhou, Guo, Zou, Liu, Wei, Wang and Feng.

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