Feedback

Role of heparanase in ARDS through autophagy and exosome pathway (review)

Affiliation
The First Clinical Medical School of Lanzhou University ,Lanzhou ,China
Feng, Fei;
Affiliation
The First Clinical Medical School of Lanzhou University ,Lanzhou ,China
Wang, Lin-Jun;
Affiliation
The First Clinical Medical School of Lanzhou University ,Lanzhou ,China
Li, Jian-Chun;
Affiliation
The First Clinical Medical School of Lanzhou University ,Lanzhou ,China
Chen, Ting-Ting;
Affiliation
The First Clinical Medical School of Lanzhou University ,Lanzhou ,China
Liu, Liping

Acute respiratory distress syndrome (ARDS) is the most common respiratory disease in ICU. Although there are many treatment and support methods, the mortality rate is still high. The main pathological feature of ARDS is the damage of pulmonary microvascular endothelium and alveolar epithelium caused by inflammatory reaction, which may lead to coagulation system disorder and pulmonary fibrosis. Heparanase (HPA) plays an significant role in inflammation, coagulation, fibrosis. It is reported that HPA degrades a large amount of HS in ARDS, leading to the damage of endothelial glycocalyx and inflammatory factors are released in large quantities. HPA can aggrandize the release of exosomes through syndecan-syntenin-Alix pathway, leading to a series of pathological reactions; at the same time, HPA can cause abnormal expression of autophagy. Therefore, we speculate that HPA promotes the occurrence and development of ARDS through exosomes and autophagy, which leads to a large amount of release of inflammatory factors, coagulation disorder and pulmonary fibrosis. This article mainly describes the mechanism of HPA on ARDS.

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

License Holder: Copyright © 2023 Feng, Wang, Li, Chen and Liu.

Use and reproduction: