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Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis

Affiliation
Department of Pharmaceutical Sciences ,Zhuhai Campus ,Zunyi Medical University ,Zhuhai ,China
Lu, Qiang;
Affiliation
Department of Pharmacology ,Zhuhai Campus ,Zunyi Medical University ,Zhuhai ,China
Xie, Yuhong;
Affiliation
China Traditional Chinese Medicine Holdings Company Limited ,Foshan ,China
Luo, Jingbin;
Affiliation
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education ,Zunyi Medical University ,Zunyi ,China
Gong, Qihai;
Affiliation
Department of Pharmacology ,Zhuhai Campus ,Zunyi Medical University ,Zhuhai ,China
Li, Cailan

Ulcerative colitis (UC) is a chronic aspecific gut inflammatory disorder that primarily involves the recta and colons. It mostly presents as a long course of repeated attacks. This disease, characterized by intermittent diarrhoea, fecal blood, stomachache, and tenesmus, severely decreases the living quality of sick persons. UC is difficult to heal, has a high recurrence rate, and is tightly related to the incidence of colon cancer. Although there are a number of drugs available for the suppression of colitis, the conventional therapy possesses certain limitations and severe adverse reactions. Thus, it is extremely required for safe and effective medicines for colitis, and naturally derived flavones exhibited huge prospects. This study focused on the advancement of naturally derived flavones from edible and pharmaceutical plants for treating colitis. The underlying mechanisms of natural-derived flavones in treating UC were closely linked to the regulation of enteric barrier function, immune-inflammatory responses, oxidative stress, gut microflora, and SCFAs production. The prominent effects and safety of natural-derived flavones make them promising candidate drugs for colitis treatment.

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License Holder: Copyright © 2023 Lu, Xie, Luo, Gong and Li.

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