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Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

ORCID
0000-0002-8347-4556
Affiliation
Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia Named after Patrice Lumumba, 117198 Moscow, Russia;(D.A.);(A.K.);(A.V.);(A.N.)
Atiakshin, Dmitri;
Affiliation
Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia Named after Patrice Lumumba, 117198 Moscow, Russia;(D.A.);(A.K.);(A.V.);(A.N.)
Kostin, Andrey;
Affiliation
Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia Named after Patrice Lumumba, 117198 Moscow, Russia;(D.A.);(A.K.);(A.V.);(A.N.)
Volodkin, Artem;
Affiliation
Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia Named after Patrice Lumumba, 117198 Moscow, Russia;(D.A.);(A.K.);(A.V.);(A.N.)
Nazarova, Anna;
ORCID
0000-0001-9185-4578
Affiliation
Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia;(V.S.);(D.E.)
Shishkina, Viktoriya;
Affiliation
Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia;(V.S.);(D.E.)
Esaulenko, Dmitry;
ORCID
0000-0003-1142-7483
Affiliation
Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia Named after Patrice Lumumba, 117198 Moscow, Russia;(D.A.);(A.K.);(A.V.);(A.N.)
Buchwalow, Igor;
Affiliation
Institute for Hematopathology, Fangdieckstr. 75a, 22547 Hamburg, Germany;
Tiemann, Markus;
Affiliation
Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 816-0811, Japan;
Noda, Mami

Knowledge of the biological effects of molecular hydrogen (H 2 ), hydrogen gas, is constantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effects of H 2 are still being actively debated. In this review, we focus on mast cells as a potential target for H 2 at the specific tissue microenvironment level. H 2 regulates the processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the capacity of the integrated-buffer metabolism and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H 2 and offers great opportunities for translating the obtained findings into clinical practice.

Category

Editor:
LeBaron, Tyler W.; Slezak, Jan
Published in:
Pharmaceuticals  
Vol. 16, No. 6 (30.05.2023)
Volume:
16
No.:
6
Date Issued:
30.05.2023
DOI:
10.3390/ph16060817
Language:
English
Type of Resource:
Text
Keywords:
molecular hydrogen; reactive oxygen intermediates; mast cells; secretome; specific mast cell proteases; local tissue microenvironment; inflammation
Subject of DNB:
610 Medical sciences Medicine

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