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Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism

Zugehörigkeit
Institute of Integrated Traditional Chinese and Western Medicine ,Tongji Hospital ,Tongji Medical College ,Huazhong University of Science and Technology ,Wuhan ,Hubei ,China
Liu, Ya-Fei;
Zugehörigkeit
Institute of Integrated Traditional Chinese and Western Medicine ,Tongji Hospital ,Tongji Medical College ,Huazhong University of Science and Technology ,Wuhan ,Hubei ,China
Wang, Huan-Huan;
Zugehörigkeit
Institute of Integrated Traditional Chinese and Western Medicine ,Tongji Hospital ,Tongji Medical College ,Huazhong University of Science and Technology ,Wuhan ,Hubei ,China
Geng, Yin-Hong;
Zugehörigkeit
Institute of Integrated Traditional Chinese and Western Medicine ,Tongji Hospital ,Tongji Medical College ,Huazhong University of Science and Technology ,Wuhan ,Hubei ,China
Han, Liang;
Zugehörigkeit
Institute of Integrated Traditional Chinese and Western Medicine ,Tongji Hospital ,Tongji Medical College ,Huazhong University of Science and Technology ,Wuhan ,Hubei ,China
Tu, Sheng-Hao;
Zugehörigkeit
Nephrology Department of Integrated Traditional Chinese and Western Medicine ,The First Affiliated Hospital of Zhengzhou University ,Zhengzhou ,Henan ,China
Wang, Hui

The prevalence of metabolic syndrome (MetS) is drastically growing worldwide, resulting in MetS-associated kidney disease. According to traditional theories, preventing blood pressure, lipid, glycose, and obesity and improving insulin resistance (IR), a couple of medications are required for MetS. It not only lowers patients’ compliance but also elevates adverse reactions. Accordingly, we attempted to seek answers from complementary and alternative medicine. Ultimately, berberine (BBR) was chosen due to its efficacy and safety on MetS through multi-pathways and multi-targets. The effects and mechanisms of BBR on obesity, IR, diabetic nephropathy, hypertension, hyperlipidemia, and hyperuricemia were elaborated. In addition, the overall properties of BBR and interventions for various kidney diseases were also collected. However, more clinical trials are expected to further identify the beneficial effects of BBR.

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