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Genetic Predisposition to Neurological Complications in Patients with COVID-19

Affiliation
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Sahajpal, Nikhil Shri;
Affiliation
Bionano Genomics, Inc., San Diego, CA 92121, USA
Hastie, Alex R.;
ORCID
0000-0001-5878-0546
Affiliation
Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany
Schieck, Maximilian;
ORCID
0000-0003-3826-9489
Affiliation
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Mondal, Ashis K.;
ORCID
0000-0001-6132-5026
Affiliation
Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany
Felde, Marc;
ORCID
0000-0003-0763-4017
Affiliation
Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands
van der Made, Caspar I.;
Affiliation
Division of Immunology, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Chou, Janet S.;
Affiliation
Department of Anesthesiology, Critical Care, and Pain Medicine, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Randolph, Adrienne G.;
ORCID
0000-0003-4284-5389
Affiliation
Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany
Illig, Thomas;
Affiliation
New York Genome Center, New York, NY 10013, USA
Zody, Michael C.;
Affiliation
Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Brownstein, Catherine A.;
ORCID
0000-0001-8818-0568
Affiliation
Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Beggs, Alan H.;
Affiliation
Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands
Hoischen, Alexander;
ORCID
0000-0002-0914-9237
Affiliation
Bionano Genomics, Inc., San Diego, CA 92121, USA
Chaubey, Alka;
ORCID
0000-0002-8283-2403
Affiliation
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Kolhe, Ravindra

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

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Editor:
Efthymiou, Stephanie
Published in:
Biomolecules  
Vol. 13, No. 1 (09.01.2023)
Volume:
13
No.:
1
Date Issued:
09.01.2023
DOI:
10.3390/biom13010133
Language:
English
Type of Resource:
Text
Keywords:
optical genome mapping; COVID-19; neurological complications; rare SVs; genetic predisposition
DDC subject of DNB:
610 Medical sciences Medicine

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License Holder: © 2023 by the authors.

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