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Ganoderma lucidum : Current advancements of characteristic components and experimental progress in anti-liver fibrosis

Affiliation
The State Key Laboratory of Southwestern Chinese Medicine Resources ,Department of Pharmacy ,Chengdu University of Traditional Chinese Medicine ,Chengdu ,China
Peng, Haoyuan;
Affiliation
Department of Pharmacy ,Personalized Drug Therapy Key Laboratory of Sichuan Province ,Sichuan Provincial People's Hospital ,School of Medicine ,University of Electronic Science and Technology of China ,Chengdu ,China
Zhong, Lei;
Affiliation
College of Medicine ,Southwest Jiaotong University ,Chengdu ,Sichuan ,China
Cheng, Lin;
Affiliation
Department of Pharmacy ,Personalized Drug Therapy Key Laboratory of Sichuan Province ,Sichuan Provincial People's Hospital ,School of Medicine ,University of Electronic Science and Technology of China ,Chengdu ,China
Chen, Lu;
Affiliation
Department of Pharmacy ,Personalized Drug Therapy Key Laboratory of Sichuan Province ,Sichuan Provincial People's Hospital ,School of Medicine ,University of Electronic Science and Technology of China ,Chengdu ,China
Tong, Rongsheng;
Affiliation
Department of Pharmacy ,Personalized Drug Therapy Key Laboratory of Sichuan Province ,Sichuan Provincial People's Hospital ,School of Medicine ,University of Electronic Science and Technology of China ,Chengdu ,China
Shi, Jianyou;
Affiliation
Department of Pharmacy ,Personalized Drug Therapy Key Laboratory of Sichuan Province ,Sichuan Provincial People's Hospital ,School of Medicine ,University of Electronic Science and Technology of China ,Chengdu ,China
Bai, Lan

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. Studies have found that G. lucidum has pharmacological effects such as antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. The main active components of G. lucidum include triterpenoids, polysaccharides, sterols, peptides and other bioactive components. Among them, the triterpenoids and polysaccharide components of G. lucidum have a wide range of anti-liver fibrotic effects. Currently, there have been more reviews and studies on the antioxidant, antitumor, and anti-aging properties of G. lucidum . Based on the current trend of increasing number of liver fibrosis patients in the world, we summarized the role of G.lucidum extract in anti-liver fibrosis and the effect of G. lucidum extract on liver fibrosis induced by different pathogenesis, which were discussed and analyzed. Research and development ideas and references are provided for the subsequent application of G. lucidum extracts in anti-liver fibrosis treatment.

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License Holder: Copyright © 2023 Peng, Zhong, Cheng, Chen, Tong, Shi and Bai.

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