Feedback

Non-coding RNA-related antitumor mechanisms of marine-derived agents

Affiliation
Institute for Translational Medicine ,The Affiliated Hospital of Qingdao University ,College of Medicine ,Qingdao University ,Qingdao ,China
Zhou, Zhixia;
Affiliation
Qingdao Central Hospital ,Central Hospital Affiliated to Qingdao University ,Qingdao ,China
Cao, Qianqian;
Affiliation
Qingdao Central Hospital ,Central Hospital Affiliated to Qingdao University ,Qingdao ,China
Diao, Yujing;
Affiliation
Institute for Translational Medicine ,The Affiliated Hospital of Qingdao University ,College of Medicine ,Qingdao University ,Qingdao ,China
Wang, Yin;
Affiliation
Institute for Translational Medicine ,The Affiliated Hospital of Qingdao University ,College of Medicine ,Qingdao University ,Qingdao ,China
Long, Linhai;
Affiliation
Qingdao Central Hospital ,Central Hospital Affiliated to Qingdao University ,Qingdao ,China
Wang, Shoushi;
Affiliation
Institute for Translational Medicine ,The Affiliated Hospital of Qingdao University ,College of Medicine ,Qingdao University ,Qingdao ,China
Li, Peifeng

In the last two decades, natural active substances have attracted great attention in developing new antitumor drugs, especially in the marine environment. A series of marine-derived compounds or derivatives with potential antitumor effects have been discovered and developed, but their mechanisms of action are not well understood. Emerging studies have found that several tumor-related signaling pathways and molecules are involved in the antitumor mechanisms of marine-derived agents, including noncoding RNAs (ncRNAs). In this review, we provide an update on the regulation of marine-derived agents associated with ncRNAs on tumor cell proliferation, apoptosis, cell cycle, invasion, migration, drug sensitivity and resistance. Herein, we also describe recent advances in marine food-derived ncRNAs as antitumor agents that modulate cross-species gene expression. A better understanding of the antitumor mechanisms of marine-derived agents mediated, regulated, or sourced by ncRNAs will provide new biomarkers or targets for potential antitumor drugs from preclinical discovery and development to clinical application.

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

License Holder: Copyright © 2022 Zhou, Cao, Diao, Wang, Long, Wang and Li.

Use and reproduction: