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From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders

Affiliation
Department of Colorectal Surgery ,The Affiliated Hospital ,Nanjing University of Chinese Medicine ,Nanjing ,Jiangsu ,China
Wu, Junbo;
Affiliation
School of Pharmaceutical Science ,Hengyang Medical School ,University of South China ,Hengyang ,Hunan ,China
Zhang, Honghua;
Affiliation
State Key Laboratory of Applied Organic Chemistry ,College of Chemistry and Chemical Engineering ,Lanzhou University ,Lanzhou ,China
Wang, Yuying;
Affiliation
School of Pharmacy ,Lanzhou University ,Lanzhou ,China
Yin, Gaofeng;
Affiliation
Tibetan Medical College ,Qinghai University ,Xining ,Qinghai ,China
Li, Qien;
Affiliation
School of Pharmaceutical Science ,Hengyang Medical School ,University of South China ,Hengyang ,Hunan ,China
Zhuo, Linsheng;
Affiliation
Department of Colorectal Surgery ,The Affiliated Hospital ,Nanjing University of Chinese Medicine ,Nanjing ,Jiangsu ,China
Chen, Hongjin;
Affiliation
School of Pharmaceutical Science ,Hengyang Medical School ,University of South China ,Hengyang ,Hunan ,China
Wang, Zhen

A novel class of benzyl-free and benzyl-substituted carbamylated tryptamine derivatives (CDTs) was designed and synthesized to serve as effective building blocks for the development of novel multi-target directed ligands (MTDLs) for the treatment of neurological disorders linked to cholinesterase (ChE) activity. The majority of them endowed butyrylcholinesterase (BuChE) with more substantial inhibition potency than acetylcholinesterase (AChE), according to the full study of ChE inhibition. Particularly, hybrids with dibenzyl groups ( 2b-2f , 2j , 2o , and 2q ) showed weak or no neuronal toxicity and hepatotoxicity and single-digit nanomolar inhibitory effects against BuChE. Through molecular docking and kinetic analyses, the potential mechanism of action on BuChE was first investigated. In vitro H 2 O 2 -induced HT-22 cells assay demonstrated the favorable neuroprotective potency of 2g , 2h , 2j , 2m , 2o , and 2p . Besides, 2g , 2h , 2j , 2m , 2o , and 2p endowed good antioxidant activities and COX-2 inhibitory effects. This study suggested that this series of hybrids can be applied to treat various ChE-associated neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), as well as promising building blocks for further structure modification to develop efficient MTDLs.

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License Holder: Copyright © 2022 Wu, Zhang, Wang, Yin, Li, Zhuo, Chen and Wang.

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