Feedback

Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)

Affiliation
Chemistry Laboratory of Natural Products ,Graduate Program in Animal Science and Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Gazim, Zilda Cristiani;
Affiliation
Molecular Biology Laboratory ,Graduate Program in Animal Science and Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Valle, Juliana Silveira;
Affiliation
Preventive Veterinary Medicine and Public Health Laboratory ,Postgraduate Program in Animal Science with an Emphasis on Bioactive Products ,Paranaense University ,Umuarama ,Brazil
Carvalho dos Santos, Isabela;
Affiliation
Chemistry Laboratory of Natural Products ,Graduate Program in Animal Science and Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Rahal, Isabelle Luiz;
Affiliation
Chemistry Laboratory of Natural Products ,Graduate Program in Animal Science and Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Silva, Gabriela Catuzo Canonico;
Affiliation
Agricultural Microbiology and Nematology Laboratory ,Graduate Program in Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Lopes, Ana Daniela;
Affiliation
Laboratory of Biotechnology of Plant Products and Microorganisms ,Postgraduate Program in Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Ruiz, Suelen Pereira;
Affiliation
Laboratory of Biotechnology of Plant Products and Microorganisms ,Postgraduate Program in Biotechnology Applied to Agriculture ,Paranaense University ,Umuarama ,Brazil
Faria, Maria Graciela Iecher;
Affiliation
Preventive Veterinary Medicine and Public Health Laboratory ,Postgraduate Program in Animal Science with an Emphasis on Bioactive Products ,Paranaense University ,Umuarama ,Brazil
Piau Junior, Ranulfo;
Affiliation
Preventive Veterinary Medicine and Public Health Laboratory ,Postgraduate Program in Animal Science with an Emphasis on Bioactive Products ,Paranaense University ,Umuarama ,Brazil
Gonçalves, Daniela Dib

Baccharis dracunculifolia DC (Lamiaceae) (Asteraceae) is found in South America, mainly in Argentina, Brazil, Bolivia, Paraguay and Uruguay. Folk medicine is used as a sedative, hypotensive, bronchodilator, cardiovascular disorders, anti-flu, and also in skin wounds. Considered the main source of green propolis, which increases the pharmacological interest in this species. It is also known as a “benefactor” plant facilitating the development of other plant species around it, being indicated for the recovery of degraded areas. This species has been studied for decades in order to isolate and identify the active principles present in the aerial parts (leaves and flowers) and roots. The present study consists of a review of the scientific literature addressing the ethnobotanical, ethnomedicinal, phytochemical, pharmacological and potential cytotoxic effects of the B. dracunculifolia species. In this survey, we sought to investigate issues related to the botanical and geographic description of the species, the ethnobotanical uses, as well as the phytochemical studies of the essential oil, extracts and green propolis obtained from the aerial parts and roots of B. dracunculifolia . Using high precision analytical tools, numerous compounds have already been isolated and identified from leaves and flowers such as the flavonoids: naringenin, acacetin, dihydrokaempferol, isosakuranetin and kaempferide; phenolic acids: p -coumaric, dihydrocoumaric, ferulic (E)-cinnamic, hydroxycinnamic, gallic, caffeic, and several caffeoylquinic acids derivatives; phenolic acids prenylated: artepillin C, baccharin, drupanin; the glycosides dracuculifosides and the pentacyclic triterpenoids: Baccharis oxide and friedelanol. The predominant class in the essential oil of leaves and flowers are terpenoids comprising oxygenated monoterpenes and sesquiterpenes, highlighting the compounds nerolidol, spathulenol, germacrene D and bicyclogermacrene. These compounds give the species high antimicrobial, antioxidant, antitumor, analgesic, immunomodulatory and antiparasitic potential, making this species a promising herbal medicine. In vitro toxicity assays with B. dracunculifolia extract showed low or no cytotoxicity. However, in vivo analyses with high doses of the aqueous extract resulted in genotoxic effects, which leads us to conclude that the toxicity of this plant is dose-dependent.

Graphical Abstract

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

License Holder: Copyright © 2022 Gazim, Valle, Carvalho dos Santos, Rahal, Silva, Lopes, Ruiz, Faria, Piau Junior and Gonçalves.

Use and reproduction: