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Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties

ORCID
0000-0003-1517-3687
Affiliation
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
Li, Yuqiang;
Affiliation
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
Wang, Dan;
Affiliation
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
Ge, Heming;
ORCID
0000-0002-5173-9492
Affiliation
Department of General Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Güngör, Cenap;
Affiliation
Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
Gong, Xuejun;
Affiliation
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
Chen, Yongheng

Cancer stem cells (CSCs) are a subpopulation of cancer cells possessing stemness characteristics that are closely associated with tumor proliferation, recurrence and resistance to therapy. Recent studies have shown that different cytoskeletal components and remodeling processes have a profound impact on the behavior of CSCs. In this review, we outline the different cytoskeletal components regulating the properties of CSCs and discuss current and ongoing therapeutic strategies targeting the cytoskeleton. Given the many challenges currently faced in targeted cancer therapy, a deeper comprehension of the molecular events involved in the interaction of the cytoskeleton and CSCs will help us identify more effective therapeutic strategies to eliminate CSCs and ultimately improve patient survival.

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