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Functions and clinical significance of circular RNAs in acute myeloid leukemia

Affiliation
School of Life Sciences ,Chongqing University ,Chongqing ,China
Zhou, Min;
Affiliation
Department of Anesthesiology ,First Affiliated Hospital of Kunming Medical University ,Kunming ,China
Gao, Xianling;
Affiliation
Department of Pharmacy ,West China Hospital ,Sichuan University ,Chengdu ,China
Zheng, Xin;
Affiliation
Department of Anesthesiology ,The First People’s Hospital of Yunnan Province ,Kunming ,China
Luo, Jing

Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of circRNAs in sponging microRNAs, modulating transcription, regulating RNA-binding proteins, as well as encoding proteins have been made very recently. Dysregulated circRNAs are associated with human diseases such as acute myeloid leukemia (AML). In this review, we focus on the recently described mechanisms, role and clinical significance of circRNAs in AML. Although great progress of circRNAs in AML has been achieved, substantial efforts are still required to explore whether circRNAs exert their biological function by other mechanisms such as regulation of gene transcription or serving as translation template in AML. It is also urgent that researchers study the machineries regulating circRNAs fate, the downstream effectors of circRNAs modulatory networks, and the clinical application of circRNAs in AML.

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License Holder: Copyright © 2022 Zhou, Gao, Zheng and Luo.

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