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The chemical components, action mechanisms, and clinical evidences of YiQiFuMai injection in the treatment of heart failure

Affiliation
Key Laboratory of Chinese Internal Medicine of MOE ,Dongzhimen Hospital ,Beijing ,China
Lv, Shichao;
Affiliation
Department of Geriatrics ,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine ,Tianjin ,China
Wang, Yunjiao;
Affiliation
Department of Geriatrics ,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine ,Tianjin ,China
Zhang, Wanqin;
Affiliation
Key Laboratory of Chinese Internal Medicine of MOE ,Dongzhimen Hospital ,Beijing ,China
Shang, Hongcai

YiQiFuMai injection (YQFM), derived from Shengmai Powder, is wildly applied in the treatment of cardiovascular diseases, such as coronary heart disease and chronic cardiac insufficiency. YiQiFuMai injection is mainly composed of Radix of Panax ginseng C.A. Mey. (Araliaceae), Radix of Ophiopogon japonicus (Thunb.) Ker Gawl (Liliaceae), and Fructus of Schisandra chinensis (Turcz.) Baill (Schisandraceae), and Triterpene saponins, steroidal saponins, lignans, and flavonoids play the vital role in the potency and efficacy. Long-term clinical practice has confirmed the positive effect of YiQiFuMai injection in the treatment of heart failure, and few adverse events have been reported. In addition, the protective effect of YiQiFuMai injection is related to the regulation of mitochondrial function, anti-apoptosis, amelioration of oxidant stress, inhibiting the expression of inflammatory mediators, regulating the expression of miRNAs, maintaining the balance of matrix metalloproteinases/tissue inhibitor of metalloproteinases (MMP/TIMP) and anti-hypoxia.

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License Holder: Copyright © 2022 Lv, Wang, Zhang and Shang.

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