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Furaquinocins K and L: Novel Naphthoquinone-Based Meroterpenoids from Streptomyces sp. Je 1-369

Affiliation
Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, 79005 Lviv, Ukraine
Tistechok, Stepan;
ORCID
0000-0003-2201-7420
Affiliation
Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany
Stierhof, Marc;
Affiliation
Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany
Myronovskyi, Maksym;
Affiliation
Department of Pharmaceutical Biology, Saarland University, 66123 Saarbruecken, Germany
Zapp, Josef;
ORCID
0000-0002-8107-0128
Affiliation
Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, 79005 Lviv, Ukraine
Gromyko, Oleksandr;
Affiliation
Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbruecken, Germany
Luzhetskyy, Andriy

Actinomycetes are the most prominent group of microorganisms that produce biologically active compounds. Among them, special attention is focused on bacteria in the genus Streptomyces . Streptomycetes are an important source of biologically active natural compounds that could be considered therapeutic agents. In this study, we described the identification, purification, and structure elucidation of two new naphthoquinone-based meroterpenoids, furaquinocins K and L, from Streptomyces sp. Je 1-369 strain, which was isolated from the rhizosphere soil of Juniperus excelsa (Bieb.). The main difference between furaquinocins K and L and the described furaquinocins was a modification in the polyketide naphthoquinone skeleton. In addition, the structure of furaquinocin L contained an acetylhydrazone fragment, which is quite rare for natural compounds. We also identified a furaquinocin biosynthetic gene cluster in the Je 1-369 strain, which showed similarity (60%) with the furaquinocin B biosynthetic gene cluster from Streptomyces sp. KO-3988. Furaquinocin L showed activity against Gram-positive bacteria without cytotoxic effects.

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