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Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis

Affiliation
College of Pharmacy ,Dalian Medical University ,Dalian ,China
Li, Wenlian;
Affiliation
College of Pharmacy ,Dalian Medical University ,Dalian ,China
Yang, Kejia;
Affiliation
College of Pharmacy ,Dalian Medical University ,Dalian ,China
Li, Bin;
Affiliation
College of Pharmacy ,Dalian Medical University ,Dalian ,China
Wang, Yunxiang;
Affiliation
College of Pharmacy ,Dalian Medical University ,Dalian ,China
Liu, Jing;
Affiliation
Comparative Medicine Department of Researching and Teaching ,Dalian Medical University ,Dalian ,China
Chen, Dapeng;
Affiliation
College of Pharmacy ,Dalian Medical University ,Dalian ,China
Diao, Yunpeng

Intestinal ischemia reperfusion (II/R) is a clinical emergency that frequently occurs in a variety of clinical conditions. Severe intestinal injury results in the release of cytotoxic substances and inflammatory mediators which can activate local inflammatory response and bacterial translocation. This triggers multi-organ failure, including lung injury, which is a common complication of II/R injury and contributes to the high mortality rate. Corilagin (Cor) is a natural ellagitannin found in a variety of plants. It has many biological and pharmacological properties, including antioxidant, anti-inflammatory and anti-apoptosis activities. However, no studies have evaluated the effects and molecular mechanisms of Cor in alleviating II/R-induced intestinal and lung damage. In this study, Cor was found to significantly alleviate II/R-induced pathological damage, inflammatory response, oxidative stress, NLRP3 inflammasome activation, and pyroptosis in intestinal and lung tissues both in vivo and in vitro . Further, Cor inhibited the NLRP3 inflammasome activation and pyroptosis in RAW264.7 and MLE-12 cells induced by LPS/nigericin and that in IEC-6 cells induced by nigericin, indicating an amelioration of Cor in II/R-induced intestinal and lung injury via inhibiting NLRP3 inflammasome activation and pyroptosis. Thus, Cor might be a potential therapeutic agent for II/R-induced inflammation and tissue injury.

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License Holder: Copyright © 2022 Li, Yang, Li, Wang, Liu, Chen and Diao.

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