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The role of IL-6 in coronavirus, especially in COVID-19

Affiliation
Department of Radiation Oncology ,The First Affiliated Hospital of Anhui Medical University ,Hefei ,Anhui ,China
Wang, Xinyi;
Affiliation
Department of Orthopaedics ,Lu’an Hospital of Anhui Medical University ,Lu’an ,Anhui ,China
Tang, Guozheng;
Affiliation
Department of Otolaryngology ,Head and Neck Surgery ,The First Affifiliated Hospital of Anhui Medical University ,Hefei ,Anhui ,China
Liu, Yuchen;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Zhang, Lizhi;
Affiliation
Department of Oncology ,The First Affiliated Hospital of Anhui Medical University ,Hefei ,Anhui ,China
Chen, Bangjie;
Affiliation
Department of Otolaryngology ,Head and Neck Surgery ,The First Affifiliated Hospital of Anhui Medical University ,Hefei ,Anhui ,China
Han, Yanxun;
Affiliation
Second Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Fu, Ziyue;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Wang, Liuning;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Hu, Guangzhi;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Ma, Qing;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Sheng, Shuyan;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Wang, Jianpeng;
Affiliation
First Clinical Medical College ,Anhui Medical University ,Hefei ,Anhui ,China
Hu, Xinyang;
Affiliation
Department of Orthopaedics ,Lu’an Hospital of Anhui Medical University ,Lu’an ,Anhui ,China
Shao, Song

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and animals and may cause significant respiratory problems, including lung illness: Corona Virus Disease 2019 (COVID-19). Swabs taken from the throat and nose of people who have the illness or are suspected of having it have shown this pathogenic virus. When SARS-CoV-2 infects the upper and lower respiratory tracts, it may induce moderate to severe respiratory symptoms, as well as the release of pro-inflammatory cytokines including interleukin 6 (IL-6). COVID-19-induced reduction of IL-6 in an inflammatory state may have a hitherto undiscovered therapeutic impact. Many inflammatory disorders, including viral infections, has been found to be regulated by IL-6. In individuals with COVID-19, one of the primary inflammatory agents that causes inflammatory storm is IL-6. It promotes the inflammatory response of virus infection, including the virus infection caused by SARS-CoV-2, and provides a new diagnostic and therapeutic strategy. In this review article, we highlighted the functions of IL-6 in the coronavirus, especially in COVID-19, showing that IL-6 activation plays an important function in the progression of coronavirus and is a rational therapeutic goal for inflammation aimed at coronavirus.

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License Holder: Copyright © 2022 Wang, Tang, Liu, Zhang, Chen, Han, Fu, Wang, Hu, Ma, Sheng, Wang, Hu and Shao.

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