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Correlation between the severity of COVID-19 vaccine-related adverse events and the blood group of the vaccinees in Saudi Arabia: A web-based survey

Affiliation
Department of Clinical Pharmacy ,College of Pharmacy ,Taif University ,Taif ,Saudi Arabia
Almalki, Ohoud S.;
Affiliation
Department of Pharmaceutics and Industrial pharmacy ,College of Pharmacy ,Taif University ,Taif ,Saudi Arabia
Khalifa, Amany S.;
Affiliation
Department of Clinical Pharmacy ,College of Pharmacy ,Taif University ,Taif ,Saudi Arabia
Alhemeidi, Ozouf F.;
Affiliation
Department of Public Health ,Faculty of Health Sciences-AlQunfudah ,Umm Al-Qura University ,Makkah ,Saudi Arabia
Ewis, Ashraf A.;
Affiliation
Department of Pharmaceutics and Industrial pharmacy ,College of Pharmacy ,Taif University ,Taif ,Saudi Arabia
Shady, Abeer M.;
Affiliation
Department of Pharmaceutics and Industrial pharmacy ,College of Pharmacy ,Taif University ,Taif ,Saudi Arabia
Abdelwahab, Sayed F.

Background: Recent epidemiological studies have reported an association between the ABO blood group and the acquisition, symptom severity, and mortality rate of coronavirus disease 2019 (COVID-19). However, the association between the ABO blood group antigens and the type and severity of COVID-19 vaccine-related adverse reactions has not been elucidated. Patients and Methods: We conducted a cross-sectional, questionnaire-based study in Saudi Arabia from February to April 2022. The study cohort included adults who had received or were willing to receive at least two doses of a COVID-19 vaccine of any type. We used Chi-square test to assess the association between the ABO blood groups and vaccine-related adverse reactions. p values of <0.05 were considered significant. Results: Of the 1180 participants, approximately half were aged 18–30 years old, 69.2% were female, and 41.6% reported their blood group as O. The most frequent COVID-19 vaccine-related adverse reactions were fatigue (65%), pain at the injection site (56%), and headache (45.9%). These adverse reactions demonstrated significant correlations with the education level ( p = 0.003) and nationality ( p = 0.018) of the participants following the first dose, with gender ( p < 0.001) following the second dose, and with the general health status ( p < 0.001) after all the doses. Remarkably, no correlation was observed between the severity of the vaccine-related adverse reactions and ABO blood groups. Conclusion: Our findings do not support a correlation between the severity of COVID-19 vaccine-related adverse reactions and the ABO blood groups of the vaccinees. The creation of a national database is necessary to account for population differences.

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License Holder: Copyright © 2022 Almalki, Khalifa, Alhemeidi, Ewis, Shady and Abdelwahab.

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