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Dissolvable hyaluronic acid microneedles loaded with β-Elemene for the treatment of psoriasis

Affiliation
College of Pharmaceutical Science ,Dali University ,Dali ,China
Wang, Chun;
Affiliation
Joint Centre of Translational Medicine ,The First Affiliated Hospital of Wenzhou Medical University ,Wenzhou ,China
Hao, Ruiqi;
Affiliation
College of Pharmaceutical Science ,Dali University ,Dali ,China
Peng, Baowei;
Affiliation
Joint Centre of Translational Medicine ,The First Affiliated Hospital of Wenzhou Medical University ,Wenzhou ,China
Chang, Jiang;
Affiliation
Department of Dermatology ,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University ,Wenzhou ,China
Chen, Shisheng;
Affiliation
Joint Centre of Translational Medicine ,The First Affiliated Hospital of Wenzhou Medical University ,Wenzhou ,China
Chen, Yanxin;
Affiliation
Joint Centre of Translational Medicine ,The First Affiliated Hospital of Wenzhou Medical University ,Wenzhou ,China
Yin, Xiaohang;
Affiliation
Joint Centre of Translational Medicine ,The First Affiliated Hospital of Wenzhou Medical University ,Wenzhou ,China
Que, Yumei;
Affiliation
Joint Centre of Translational Medicine ,The First Affiliated Hospital of Wenzhou Medical University ,Wenzhou ,China
Fan, Chen;
Affiliation
College of Pharmaceutical Science ,Dali University ,Dali ,China
Xu, Yuhong

The pathology of psoriasis involves the over-proliferation of keratinocytes, exaggerated inflammation of keratinocytes, and infiltration of inflammatory cells such as macrophages (Mø), etc. The therapeutic outcomes of current treatment targeting one single pathological process are less than satisfactory. Based on their diverse biological activities, natural products offer a potential solution to this problem. In this study, we investigated the effects of β-Elemene (ELE) on both psoriatic keratinocytes and M1-type Mø (M1-Mø) in vitro . Hyaluronic acid (HA) microneedles loaded with ELE (HA-ELE-MN) were also fabricated and tested for the treatment of psoriasis in vivo using an imiquimod (IMQ)-induced psoriatic mice model. Our data suggest that ELE induces apoptosis and inhibits inflammation of psoriatic keratinocytes. In addition, ELE attenuates the expression of inflammatory cytokines secreted from M1-Mø, thus indirectly inhibiting the inflammation of keratinocytes. Furthermore, HA-ELE-MN has been found to significantly alleviate symptoms in an IMQ-induced psoriatic mice model by inducing keratinocytes apoptosis, suppressing keratinocytes proliferation, and inhibiting M1-Mø infiltration. Taken together, this study demonstrates that ELE can be used for the treatment of psoriasis by targeting both keratinocytes and M1-Mø, which provides a potential novel reagent for psoriasis treatment.

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License Holder: Copyright © 2022 Wang, Hao, Peng, Chang, Chen, Chen, Yin, Que, Fan and Xu.

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