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Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis

Affiliation
School of Clinical Medicine ,Chengdu University of Traditional Chinese Medicine ,Chengdu ,China
Bao, Jie;
Affiliation
School of Clinical Medicine ,Chengdu University of Traditional Chinese Medicine ,Chengdu ,China
Chen, Chu;
Affiliation
School of Clinical Medicine ,Chengdu University of Traditional Chinese Medicine ,Chengdu ,China
Yan, Jiayu;
Affiliation
School of Basic Medicine ,Chengdu University of Traditional Chinese Medicine ,Chengdu ,China
Wen, Yueqiang;
Affiliation
School of Stomatology ,North Sichuan Medical College ,Nanchong ,China
Bian, Jiamin;
Affiliation
Department of Stomatology ,Sichuan Integrated Traditional and Western Medicine Hospital ,Chengdu ,China
Xu, Mengting;
Affiliation
Department of Stomatology ,Pengzhou Hospital of Traditional Chinese Medicine ,Pengzhou ,China
Liang, Qin;
Affiliation
Department of Neurological ,Chongqing Shi Yong Chuan Hospital of Traditional Chinese Medicine ,Chongqing ,China
He, Qingmei

Aims: This study aimed to systematically review the efficacy and safety of antioxidants for patients with Oral lichen planus (OLP). Methods: Databases, including PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar, were searched up to 30 April 2022, for randomized controlled trials on the antioxidant therapy of OLP. The following endpoints were analyzed: pain score, clinical score, pain resolution rate, clinical resolution rate, and adverse effects. Results: A total of 19 studies met the inclusion criteria, and 17 studies with 704 patients were included in the meta-analysis. The findings showed that antioxidant therapy could significantly reduce the pain score [standardized mean difference −0.72 (−1.36, −0.07), P = 0.03, I 2 = 87%, PI 2 < 0.00001] and clinical score [ SMD −2.06 (−3.06, −1.06), P < 0.0001, I 2 = 94%, PI 2 < 0.00001] of patients with OLP and improve the pain resolution rate [risk ratio (RR) 1.15 (1.01, 1.31), P = 0.04, I 2 = 45%, PI 2 = 0.09] and clinical resolution rate [ RR 1.40 (1.10, 1.78), P = 0.006, I 2 = 72%, PI 2 = 0.002]. Conclusion: The study demonstrated that antioxidant therapy was beneficial for patients with OLP, and antioxidants might be used to treat OLP. Systematic Review Registration: https://clinicaltrials.gov/ , identifier CRD4202233715.

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License Holder: Copyright © 2022 Bao, Chen, Yan, Wen, Bian, Xu, Liang and He.

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