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Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

Affiliation
Department of Pharmaceutical Biomaterials ,Faculty of Pharmacy ,Tehran University of Medical Sciences ,Tehran ,Iran
Mohajeri, Sahar;
Affiliation
Department of Pharmaceutical Biomaterials ,Faculty of Pharmacy ,Tehran University of Medical Sciences ,Tehran ,Iran
Moayedi, Saeed;
Affiliation
Faculty of Food Science and Technology ,Gorgan University of Agricultural Sciences and Natural Resources ,Gorgan ,Iran
Mohajeri, Shabnam;
Affiliation
Foodborne and Waterborne Diseases Research Center ,Research Institute for Gastroenterology and Liver Diseases ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Yadegar, Abbas;
Affiliation
Department of Pharmaceutical Biomaterials ,Faculty of Pharmacy ,Tehran University of Medical Sciences ,Tehran ,Iran
Haririan, Ismaeil

Inflammatory bowel disease (IBD) is a gastrointestinal disorder, affecting about several million people worldwide. Current treatments fail to adequately control some clinical symptoms in IBD patients, which can adversely impact the patient’s quality of life. Hence, the development of new treatments for IBD is needed. Due to their unique properties such as biocompatibility and sustained release of a drug, biomaterials-based drug delivery systems can be regarded as promising candidates for IBD treatment. It is noteworthy that considering the pathophysiological changes occurred in the gastrointestinal tract of IBD patients, especially changes in pH, surface charge, the concentration of reactive oxygen species, and the expression of some biomolecules at the inflamed colon, can help in the rational design of biomaterials-based drug delivery systems for efficient management of IBD. Here, we discuss about targeting these pathophysiological changes using biomaterials-based drug delivery systems, which can provide important clues to establish a strategic roadmap for future studies.

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License Holder: Copyright © 2022 Mohajeri, Moayedi, Mohajeri, Yadegar and Haririan.

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