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From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders

Affiliation
Department of Medical Informatics ,Faculty of Medicine ,Mashhad University of Medical Sciences ,Mashhad ,Iran
Norouzkhani, Narges;
Affiliation
Preclinical, Cardiovascular Imaging Core Facility ,Tehran University of Medical Sciences ,Tehran ,Iran
Karimi, Arian Ghannadi;
Affiliation
Pharmaceutical Sciences Research Center ,Tehran Medical Sciences ,Islamic Azad University ,Tehran ,Iran
Badami, Negar;
Affiliation
Student Research Committee ,Tabriz University of Medical Sciences ,Tabriz ,Iran
Jalalifar, Erfan;
Affiliation
Student Research Committee ,School of Medicine ,Iran University of Medical Sciences ,Tehran ,Iran
Mahmoudvand, Behnaz;
Affiliation
Student Research Committee ,School of Medicine ,North Khorasan University of Medical Sciences ,Bojnurd ,Iran
Ansari, Arina;
Affiliation
School of Medicine ,Urmia University of Medical Sciences ,Urmia ,Iran
Pakrou Sariyarighan, Neda;
Affiliation
Student Research committee ,School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Alijanzadeh, Dorsa;
Affiliation
Student Research Committee ,Esfahan University of Medical Sciences ,Esfahan ,Iran
Aghakhani, Sara;
Affiliation
Faculty of Veterinary Medicine ,Amol University of Special Modern Technologies ,Amol ,Iran
Shayestehmehr, Reza;
Affiliation
Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Arzaghi, Mohammadreza;
Affiliation
Babol University of Medical Sciences ,Babol ,Iran
Sheikh, Zahra;
Affiliation
Student Research Committee ,Kermanshah University of Medical Sciences ,Kermanshah ,Iran
Salami, Yasaman;
Affiliation
Student Research Committee ,School of Medicine ,Tehran Medical Sciences ,Islamic Azad University ,Tehran ,Iran
Marabi, Mohammad Hesam;
Affiliation
Student Research Committee ,School of Medicine ,Tehran Medical Sciences ,Islamic Azad University ,Tehran ,Iran
Abdi, Amir;
Affiliation
Student Research committee ,School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Deravi, Niloofar

Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These days, studies on plant efficacy in traditional medicine are being conducted because herbal medicine is affordable, safe, and culturally acceptable and easily accessible. The Indian traditional medicine system called Ayurveda uses several herbs and medicinal plants to treat various disorders including neurological disorders. This review aims to summarize the data on the neuroprotective potential of the following common Indian spices widely used in Ayurveda: cumin ( Cuminum cyminum (L.), Apiaceae), black cumin ( Nigella sativa (L.), Ranunculaceae), black pepper ( Piper nigrum (L.), Piperaceae), curry leaf tree ( Murraya koenigii (L.), Spreng Rutaceae), fenugreek ( Trigonella foenum-graecum (L.), Fabaceae), fennel ( Foeniculum vulgare Mill, Apiaceae), cardamom ( Elettaria cardamomum (L.) Maton, Zingiberaceae), cloves ( Syzygium aromaticum (L.) Merr. & L.M.Perry, Myrtaceae), and coriander ( Coriandrum sativum (L.), Apiaceae) in age-related neurological disorders.

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License Holder: Copyright © 2022 Norouzkhani, Karimi, Badami, Jalalifar, Mahmoudvand, Ansari, Pakrou Sariyarighan, Alijanzadeh, Aghakhani, Shayestehmehr, Arzaghi, Sheikh, Salami, Marabi, Abdi and Deravi.

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