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The modulation of gut microbiota by herbal medicine to alleviate diabetic kidney disease – A review

Affiliation
Shandong University of Traditional Chinese Medicine ,Jinan ,China
Du, Jinxin;
Affiliation
NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences) ,Biomedical Sciences College ,Shandong First Medical University ,Jinan ,China
Yang, Meina;
Affiliation
Shandong Key Laboratory of Rheumatic Disease and Translational Medicine ,Department of Endocrinology and Metabology ,The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital ,Jinan ,China
Zhang, Zhongwen;
Affiliation
NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences) ,Biomedical Sciences College ,Shandong First Medical University ,Jinan ,China
Cao, Baorui;
Affiliation
NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences) ,Biomedical Sciences College ,Shandong First Medical University ,Jinan ,China
Wang, Zhiying;
Affiliation
NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences) ,Biomedical Sciences College ,Shandong First Medical University ,Jinan ,China
Han, Jinxiang

The treatment of diabetic kidney disease (DKD) has been the key concern of the medical community. Herbal medicine has been reported to alleviate intestinal dysbiosis, promote the excretion of toxic metabolites, and reduce the secretion of uremic toxins. However, the current understanding of the modulation of the gut microbiota by herbal medicine to delay the progression of DKD is still insufficient. Consequently, we reviewed the knowledge based on peer-reviewed English-language journals regarding regulating gut microbiota by herbal medicines in DKD. It was found that herbal medicine or their natural extracts may have the following effects: modulating the composition of intestinal flora, particularly Akkermansia , Lactobacillus , and Bacteroidetes , as well as adjusting the F/B ratio; increasing the production of SCFAs and restoring the intestinal barrier; reducing the concentration of uremic toxins (p-cresol sulfate, indole sulfate, TMAO); inhibiting inflammation and oxidative stress.

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License Holder: Copyright © 2022 Du, Yang, Zhang, Cao, Wang and Han.

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