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The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Affiliation
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing ,College of Pharmacy ,Hubei University of Chinese Medicine ,Wuhan ,China
Wang, Zijun;
Affiliation
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing ,College of Pharmacy ,Hubei University of Chinese Medicine ,Wuhan ,China
Li, Lanqing;
Affiliation
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing ,College of Pharmacy ,Hubei University of Chinese Medicine ,Wuhan ,China
Wang, Shunshun;
Affiliation
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing ,College of Pharmacy ,Hubei University of Chinese Medicine ,Wuhan ,China
Wei, Jing;
Affiliation
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing ,College of Pharmacy ,Hubei University of Chinese Medicine ,Wuhan ,China
Qu, Linghang;
Affiliation
Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area ,Chongqing Engineering Research Center of Antitumor Natural Drugs ,Chongqing Three Gorges Medical College ,Chongqing ,China
Pan, Lianhong;
Affiliation
Hubei Engineering Technology Research Center of Chinese Materia Medica Processing ,College of Pharmacy ,Hubei University of Chinese Medicine ,Wuhan ,China
Xu, Kang

Cancer is the second leading cause of elevated mortality worldwide. Thus, the development of drugs and treatments is needed to enhance the survival rate of the cancer-affected population. Recently, gut microbiota research in the healthy development of the human body has garnered widespread attention. Many reports indicate that changes in the gut microbiota are strongly associated with chronic inflammation-related diseases, including colitis, liver disease, and cancer within the intestine and the extraintestinal tract. Different gut bacteria are vital in the occurrence and development of tumors within the gut and extraintestinal tract. The human gut microbiome has significant implications for human physiology, including metabolism, nutrient absorption, and immune function. Moreover, diet and lifestyle habits are involved in the evolution of the human microbiome throughout the lifetime of the host and are involved in drug metabolism. Probiotics are a functional food with a protective role in cancer development in animal models. Probiotics alter the gut microbiota in the host; thus, beneficial bacterial activity is stimulated, and detrimental activity is inhibited. Clinical applications have revealed that some probiotic strains could reduce the occurrence of postoperative inflammation among cancer patients. An association network was constructed by analyzing the previous literature to explore the role of probiotics from the anti-tumor perspective. Therefore, it provides direction and insights for research on tumor treatment.

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License Holder: Copyright © 2022 Wang, Li, Wang, Wei, Qu, Pan and Xu.

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