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Role of microbes in colorectal cancer therapy: Cross-talk between the microbiome and tumor microenvironment

Affiliation
Department of Gastrointestinal Surgery ,The Second Affiliated Hospital of Dalian Medical University ,Dalian ,China
Xia, Cong;
Affiliation
Affiliated Foshan Maternity and Child Healthcare Hospital ,Southern Medical University ,Foshan ,China
Cai, Yantao;
Affiliation
Department of Gastrointestinal Surgery ,The Second Affiliated Hospital of Dalian Medical University ,Dalian ,China
Ren, Shuangyi;
Affiliation
Affiliated Foshan Maternity and Child Healthcare Hospital ,Southern Medical University ,Foshan ,China
Xia, Chenglai

The human gut microbiota is associated with the development and progression of colorectal cancer, and manipulation of the gut microbiota is a novel strategy for the prevention and treatment of colorectal cancer. Some bacteria have antitumor activity against colorectal cancer, where specific bacteria can improve the tumor microenvironment, activate immune cells including dendritic cells, helper T cells, natural killer cells, and cytotoxic T cells, and upregulate the secretion of pro-tumor immune cytokines such as interleukin-2 and interferon. In this paper, we summarize some bacteria with potential benefits in colorectal cancer and describe their roles in the tumor microenvironment, demonstrate the application of gut microbes in combination with immunosuppressive agents, and provide suggestions for further experimental studies and clinical practice applications.

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License Holder: Copyright © 2022 Xia, Cai, Ren and Xia.

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