The benefits of propofol on cancer treatment: Decipher its modulation code to immunocytes

First Operating Room ,First Hospital of Jilin University ,Changchun ,China
Gu, Long;
Intensive Care Unit ,First Affiliated Hospital to Changchun University of Chinese Medicine ,Changchun ,China
Pan, Xueqi;
Trauma Center ,Shandong Provincial Hospital Affiliated to Shandong First Medical University ,Jinan ,China
Wang, Chongcheng;
Department of Pediatric Neurology ,First Hospital of Jilin University ,Jilin University ,Changchun ,China
Wang, Lei

Anesthetics are essential for cancer surgery, but accumulated research have proven that some anesthetics promote the occurrence of certain cancers, leading to adverse effects in the lives of patients. Although anesthetic technology is mature, there is no golden drug selection standard for surgical cancer treatment. To afford the responsibility of human health, a more specific regimen for cancer resection is indeed necessary. Immunosuppression in oncologic surgery has an adverse influence on the outcomes of patients. The choice of anesthetic strategies influences perioperative immunity. Among anesthetics, propofol has shown positive effects on immunity. Apart from that, propofol’s anticancer effect has been generally reported, which makes it more significant in oncologic surgery. However, the immunoregulative function of propofol is not reorganized well. Herein, we have summarized the impact of propofol on different immunocytes, proposed its potential mechanism for the positive effect on cancer immunity, and offered a conceivable hypothesis on its regulation to postoperative inflammation. We conclude that the priority of propofol is high in oncologic surgery and propofol may be a promising immunomodulatory drug for tumor therapy.


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