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Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

Affiliation
University Institute of Pharma Sciences ,Chandigarh University ,Mohali ,Punjab ,India
Kabra, Atul;
Affiliation
University School of Pharmaceutical Sciences ,Rayat Bhara University ,Mohali ,Punjab ,India
Garg, Ruchika;
Affiliation
Natural Products for Neuroprotection and Anti-Ageing Research Unit ,Chulalongkorn University ,Bangkok ,Thailand
Brimson, James;
Affiliation
Department for Pharmaceutical Research and Development ,Institute for Medicinal Plants Research “Dr. Josif Pančić” ,Belgrade ,Serbia
Živković, Jelena;
Affiliation
Department of Pharmaceutical Sciences ,College of Pharmacy ,Shaqra University ,Shaqra ,Saudi Arabia
Almawash, Saud;
Affiliation
Department of Pharmacy ,Faculty of Biological Sciences ,University of Malakand ,Chakdara ,Pakistan
Ayaz, Muhammad;
Affiliation
Department of Pharmacy ,Faculty of Biological Sciences ,University of Malakand ,Chakdara ,Pakistan
Nawaz, Asif;
Affiliation
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs ,School of Pharmacy ,Shanghai Jiao Tong University ,Shanghai ,China
Hassan, Syed Shams Ul;
Affiliation
Department of Pharmacy ,Faculty of Medicine and Pharmacy ,University of Oradea ,Oradea ,Romania
Bungau, Simona

Depression is a condition characterized by low mood and an aversion to activity, that causes behavioral problems, poor quality of life and limits daily life activities. It is considered as the fourth leading cause of disability worldwide. Selective Serotonin Reuptake Inhibitors (SSRIs) Monoamine Oxidase (MAO) inhibitors, Tricyclic Antidepressants (TCAs), and atypical antidepressants are some of the conventional medications used to treat depression. However, only about half of patients with major depressive disorder (MDD) respond effectively to first-line antidepressant therapy. Additionally, there are a number of drawbacks to standard antidepressants, such as anti-cholinergic side effects, drug-drug interactions, and food-drug interactions, which prompts researchers to look at alternative approaches to the treatment of depression. Medicinal plants and their metabolites are extensively tested for their efficacy against depression. Electronic databases such as Google scholar, Science Direct, SciFinder and PubMed were used to search relevant literature on the role of polyphenols in depression. Plants-derived Polyphenols represent a major class of compounds extensively distributed in plants. Number of polyphenols have demonstrated antidepressant activity, among which berberine, piperine, curcumin, naringenin, ascorbic acid and ginsenosides are extensively evaluated. The medicinal plants and their derived compounds mediated synthesized green nanoparticles have also exhibited considerable efficacy in the management of depression. The therapeutic effects of these phytochemicals is mediated via differentiation and inhibition of neuronal cell apoptosis, promotion of neuronal cell survival and modulation of key neurotransmitters. The aim of this study is to review compressively the chemical, pharmacological and neurological evidence showing the potential of polyphenols in depression.

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License Holder: Copyright © 2022 Kabra, Garg, Brimson, Živković, Almawash, Ayaz, Nawaz, Hassan and Bungau.

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